Protein C (PROC) Rabbit Monoclonal Antibody [Clone ID: HPC-4]
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Specifications
Product Data | |
Clone Name | HPC-4 |
Applications | Bl, ELISA |
Reactivities | Human |
Modifications | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
Host | Rabbit |
Isotype | IgG, kappa |
Clonality | Monoclonal |
Immunogen | This antibody was raised by immunising mice with human protein C. |
Specificity | Specifically binds to a specific twelve peptide sequence (EDQVDPRLIDGK) in the activation region of the Protein C (spanning the thrombin cleavage site). Does not react with activated protein C. Has been shown to be cross-reactive with baboon Protein C but not with bovine or mouse Protein C. HPC-4 binds human protein C only in the presence of Ca2, it binds to the reduced carboxymethylated protein C heavy chain and it blocks protein C activation but does not bind or inactivate protein C or activated protein C bound to its plasma inhibitor (Taylor et al., 1987). It is an anti-epitope tag antibody, as it recognises EDQVDPRLIDGK sequence (Taylor et al., 1987). Furthermore, it has been shown to work in ELISAs to detemine expression levels (Velander et al., 1992). HPC-4 has been shown to be effective at purifying proteins tagged with its epitope (Rezaie et al., 1992). Has been used to block the activation of Protein C by the thrombin-thrombomodullin complex (Stearns et al., 1988). It was used for the same purpose in Baboons to lower the threshold of sepsis (Taylor Jr et al., 1987). HPC-4 has been used in many other studies to observe the function of Protein C by knocking out its function in a Ca2+ dependent manner, purificaion and others (Bae et al., 2007; Tanaka et al., 2005). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Stability | 3 years from dispatch. |
Gene Name | protein C, inactivator of coagulation factors Va and VIIIa |
Database Link | |
Synonyms | APC; PC; PROC1 |
Reference Data |
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