Il17a Mouse Monoclonal Antibody [Clone ID: MM17F3]

CAT#: TA386292

Recombinant Anti-IL-17A (Clone MM17F3)

Specifications

Product Data

• Clone Name: MM17F3
• Applications: Bl, ELISA
• Reactivities: Mouse
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: This antibody was raised by immunising C57Bl/6 mice with IL-17A cross-linked to ovalbumin to generate a highly immunogenic complex.
• Specificity: This antibody is highly specific for murine IL-17A; in ELISA analysis, no cross-reactivity with IL‐17B, IL‐17C, IL‐17D, IL‐17E or IL‐17F was observed.
  
  The specificity of this antibody has been confirmed in ELISA analysis (Uyttenhove et al, 2006). This antibody inhibits IL‐17A‐induced IL‐6 production by a Cl1D fibroblastic cell line in vitro (Uyttenhove et al, 2006). This antibody has been shown to prevent experimental autoimmune encephalomyelitis (EAE) disease development in vivo (Uyttenhove et al, 2006), as well as protecting C57Bl/6 mice from myelin oligdendrocyte glycoprotein (MOG)-induced EAE (Uyttenhove et al, 2007). Additionally, administration of this antibody inhibits collagen-induced arthritis (CIA) in IFN-γ receptor knockout mice (Kelchtermans et al, 2009).
• Formulation: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Gene Name: interleukin 17A
• Database Link:
  Entrez Gene 16171 Mouse
  UniProt ID Q62386
• Synonyms: CTLA-8; CTLA8; IL-17; IL-17A; IL17