TAK1 (MAP3K7) Rabbit Polyclonal Antibody

CAT#: TA392659

Tak1 (phospho-T184) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Tak1 around the phosphorylation site of Threonine 184.
• Specificity: Tak1 (phospho-T184) polyclonal antibody detects endogenous levels of Tak1 protein when phosphorylated at Thr184.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~70, 82 kDa
• Gene Name: mitogen-activated protein kinase kinase kinase 7
• Database Link:
  Entrez Gene 6885 Human
  UniProt ID O43318
• Background: Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a protein with intrinsic kinase activity towards serine/threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction. Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.
• Synonyms: MAP3K7; Mitogen-activated protein kinase kinase kinase 7; TAK1; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
• Note: For research use only, not for use in diagnostic procedure.