Telomerase reverse transcriptase (TERT) Rabbit Polyclonal Antibody

CAT#: TA392661

TERT (phospho-S824) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human TERT around the phosphorylation site of Serine 824.
• Specificity: p-TERT (S824) polyclonal antibody detects endogenous levels of TERT protein when phosphorylated at Ser824.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 127 kDa
• Gene Name: telomerase reverse transcriptase
• Database Link:
  Entrez Gene 7015 Human
  UniProt ID O14746
• Background: Telomerase is an RNA-dependent DNA polymerase that catalyzes the addition of telomeric repeat sequences to chromosome ends. In most human somatic cells, telomerase activity is undetectable, and telomeres shorten with successive cell divisions. However, telomerase activity is detectable in immortal cells and in many human tumors. Two candidate mammalian telomerase proteins have been cloned. Human TP1 (for telomerase-associated protein 1), also designated TLP1 in rat (for telomerase protein component 1), is homologous to the Tetrahymena p80 telomerase protein and has been shown to interact with mammalian telomerase RNA. Human TERT (for telomerase reverse transcriptase), also designated hEST2 (for ever shorter telomeres), is homologous to the p123 telomerase protein from Euplotes and to the yeast Est2 protein. Expression of TERT mRNA has been shown to correlate with telomerase activity in various cell lines.
• Synonyms: EST2; HEST2; TCS1; Telomerase-associated protein 2; Telomerase catalytic subunit; Telomerase reverse transcriptase; TERT; TP2; TRT
• Note: For research use only, not for use in diagnostic procedure.