DAXX Rabbit Polyclonal Antibody

CAT#: TA392902

Daxx (phospho-S668) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human Daxx around the phosphorylation site of Serine 668.
• Specificity: Daxx (phospho-S668) polyclonal antibodydetects endogenous levels of Daxx protein only when phosphorylated at Ser668.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 110 kDa
• Gene Name: death-domain associated protein
• Database Link:
  Entrez Gene 1616 Human
  UniProt ID Q9UER7
• Background: Apoptosis, or programmed cell death, occurs duringnormal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED3 protease family. A novel DD containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx is a death domain containing important intermediate in the Fas mediated apoptosis. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N terminal kinase (JNK) pathway. It is widely expressed in fetal and adult human and mouse tissue, indicating its important function in Fas signaling pathways.
• Synonyms: BING2; DAP6; DAXX; Daxx; Death domain-associated protein 6; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; hDaxx
• Note: For research use only, not for use in diagnostic procedure.