ZIP Kinase (DAPK3) Rabbit Polyclonal Antibody

CAT#: TA392950

DAPK3 (phospho-T265) polyclonal antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500~1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic phosphopeptide derived from human DAPK3 around the phosphorylation site of Thr265.
• Specificity: DAPK3 (phospho-T265) polyclonal antibody detects endogenous levels of DAPK3 protein when phosphorylated at Thr265.
• Formulation: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Predicted Protein Size: ~ 52 kDa
• Gene Name: death associated protein kinase 3
• Database Link:
  Entrez Gene 1613 Human
  UniProt ID O43293
• Background: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.
• Synonyms: Dapk 3; Dapk3; DAP kinase 3; DAP like kinase; Death associated kinase 3; Death associated protein kinase 3; Dlk; ZIP; ZIP-kinase; ZIPK; ZIP kinase
• Note: For research use only, not for use in diagnostic procedure.