ICAD (DFFA) Mouse Monoclonal Antibody [Clone ID: OTI1B10]

CAT#: TA500061

Anti-DFF45 (ICAD) mouse monoclonal antibody, clone OTI1B10 (formerly 1B10)

Size: 30 ul 100 ul

Formulation: Standard Carrier Free


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USD 379.00

In Stock*

Size
    • 100 ul

Other products for "DFFA"

Specifications

Product Data
Clone Name OTI1B10
Applications IF, WB
Recommended Dilution WB: 1:500, IF (1:100)
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant protein expressed in E.coli corresponding to amino acids 1-331 of human DFF45
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 36.3 kDa
Gene Name DNA fragmentation factor subunit alpha
Background Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene
Synonyms DFF-45; DFF1; ICAD
Reference Data
Protein Pathways Apoptosis

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