MEK4 (MAP2K4) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1D6]
CAT#: TA500428BM
Anti-MAP2K4 (MEK4) mouse monoclonal antibody, clone OTI1D6 (formerly 1D6), HRP conjugated
Other products for "MAP2K4"
Specifications
Product Data | |
Clone Name | OTI1D6 |
Applications | IF, IHC, IP, WB |
Recommended Dilution | WB 1:2000, IHC 1:150, IF 1:100, IP 2ug/500ul |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Full-length protein expressed in 293T cell transfected with human MAP2K4 expression vector |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 44.3 kDa |
Gene Name | mitogen-activated protein kinase kinase 4 |
Database Link | |
Background | This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. |
Synonyms | JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway |
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