Cyclin A1 (CCNA1) Rabbit Polyclonal Antibody

CAT#: TA590168

Rabbit Polyclonal Cyclin A1 Antibody

Product Images

ELISA: Cyclin A1 Antibody

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  Immunohistochemistry: Cyclin A1 Antibody - Most of the normal tissues displayed strong cytoplasmic and/or nuclear positivity. Malignant tissues exhibited moderate cytoplasmic and occasional nuclear immunoreactivity. Several thyroid and liver cancers and a few cases of colo-rectal, ovarian and renal cancers showed strong staining. Image and statement courtesy of the Human Protein Atlas (HPA).

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:10-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 0.93942 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cyclin A1
• Database Link:
  NP_003905
  Entrez Gene 8900 Human
  UniProt ID P78396
• Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CT146
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Cell cycle, Pathways in cancer, Progesterone-mediated oocyte maturation