Ku80 (XRCC5) Rabbit Polyclonal Antibody

CAT#: TA590469

Rabbit Polyclonal Ku80 Antibody

Product Images

ELISA: Ku80 Antibody

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  Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

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  Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

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  Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

• Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

• Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-XRCC5 rabbit polyclonal antibody. (TA590469)

• HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY XRCC5 (RC210649, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC5. Positive lysates LY412062 (100ug) and LC412062 (20ug) can be purchased separately from OriGene.

• Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-XRCC5 polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

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Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
• Reactivities: Human, Monkey, Mouse, Dog
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 1.01mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: X-ray repair cross complementing 5
• Database Link:
  NP_066964
  Entrez Gene 22596 MouseEntrez Gene 478902 DogEntrez Gene 574279 MonkeyEntrez Gene 7520 Human
  UniProt ID P13010
• Background: Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.
• Synonyms: KARP-1; KARP1; KU80; Ku86; KUB2; NFIV
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Non-homologous end-joining