PMS2 Rabbit Polyclonal Antibody

CAT#: TA590795

Rabbit Polyclonal PMS2 Antibody

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PMS2 (RC210880, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PMS2. Positive lysates LY424658 (100ug) and LC424658 (20ug) can be purchased separately from OriGene.

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  ELISA: PMS2 Antibody

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  Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

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  Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

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  Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

• Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

• Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-PMS2 Rabbit Polyclonal antibody. (TA590795)

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Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB 1:20000, IHC 1:150,ELISA 1:100-1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DNA immunization. This antibody is specific for the Middle Region of the target protein.
• Formulation: 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
• Concentration: 0.96mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: PMS1 homolog 2, mismatch repair system component
• Database Link:
  NP_000526
  Entrez Gene 5395 Human
  UniProt ID P54278
• Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
• Synonyms: HNPCC4; PMS2CL; PMSL2
• Note: This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Mismatch repair