PGP9.5 (UCHL1) Mouse Monoclonal Capture Antibody [Clone ID: OTI8E3]

CAT#: TA600568

UCHL1 mouse monoclonal antibody, clone OTI8E3

Specifications

Product Data

• Clone Name: OTI8E3
• Applications: ELISA
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human UCHL1 (NP_004172) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 24.8 kDa
• Gene Name: ubiquitin C-terminal hydrolase L1
• Database Link:
  NP_004172
  Entrez Gene 7345 Human
  UniProt ID P09936
• Background: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons, expressed specifically in neurons and testis/ovary. UCHL1 has been proposed as a candidate biomarker for brain injury. Baseline levels of the biomarker UCHL1 measured in cerebral spinal fluid (CSF) are predictive of long-term multiple sclerosis (MS) progression. Recent studies have demonstrated that UCHL1 could be a potential biomarker for multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, aggressive multiple myeloma and for discriminating the Parkinson’s disease.
• Synonyms: HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease