Serum Amyloid A (SAA1) Biotinylated Mouse Monoclonal Detection Antibody [Clone ID: OTI7A4]

CAT#: TA700569

SAA1 biotinylated mouse monoclonal antibody, clone OTI7A4


USD 447.00

2 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name OTI7A4
Applications ELISA
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment of human SAA (NP_954630) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Predicted Protein Size 13.5 kDa
Gene Name serum amyloid A1
Background Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis. Mature SAA1 consists of 104 amino acids with an apparent molecular weight of 12,500. Native SAA1 is a hexamer with each subunit assuming an antiparallel 4-helix bundle structure. SAA1 is highly inducible. Inflammatory cytokines such as IL-1β, IL-6 and TNF-α are major stimulants for hepatocyte expression of the SAA1 gene. Inducible expression of the acute-phase SAA genes involves the transcription factors C/EBP, NF-κB, AP2, SAF, Sp1 and STAT3. SAA1 has been a clinical indicator and reliable biomarker for inflammatory diseases, chronic metabolic disorders and late-stage malignancy.
Synonyms PIG4; SAA; SAA2; TP53I4
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.