Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: OTI3D3]
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Other products for "APOE"
Specifications
Product Data | |
Clone Name | OTI3D3 |
Applications | IHC, WB |
Recommended Dilution | WB 1:500, IHC 1:150 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human APOE (NP_000032) produced in HEK293T cell. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 34.2 kDa |
Gene Name | apolipoprotein E |
Database Link | |
Background | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008] |
Synonyms | AD2; APO-E; LDLCQ5; LPG |
Reference Data | |
Protein Families | Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency |
Protein Pathways | Alzheimer's disease |
Documents
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Resources
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