RET Mouse Monoclonal Antibody [Clone ID: OTI5C7]
CAT#: TA805707
RET mouse monoclonal antibody, clone OTI5C7 (formerly 5C7)
Size: 30 ul
Formulation: Carrier Free
Specifications
Product Data | |
Clone Name | OTI5C7 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivities | Human, Rat |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 713-1017 of human RET(NP_066124) produced in E.coli. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 124.1 kDa |
Gene Name | ret proto-oncogene |
Database Link | |
Background | This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] |
Synonyms | CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
Protein Pathways | Endocytosis, Pathways in cancer, Thyroid cancer |
Documents
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Resources
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