Factor XIII (F13B) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2H10]
CAT#: TA805993AM
F13B mouse monoclonal antibody, clone OTI2H10 (formerly 2H10), Biotinylated
Other products for "F13B"
Specifications
Product Data | |
Clone Name | OTI2H10 |
Applications | WB |
Recommended Dilution | WB 1:200 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 357-661 of human F13B(NP_001985) produced in E.coli. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Biotin |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 73.2 kDa |
Gene Name | coagulation factor XIII B chain |
Database Link | |
Background | This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul |
Synonyms | FXIIIB |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Complement and coagulation cascades |
Documents
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