Endothelin 3 (EDN3) Mouse Monoclonal Antibody [Clone ID: OTI3E10]

CAT#: TA808598

EDN3 mouse monoclonal antibody,clone OTI3E10

Product Images

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3min, TA808598) (1:150)

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  Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3min, TA808598) (1:150)

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  Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-EDN3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3min, TA808598) (1:150)

Specifications

Product Data

• Clone Name: OTI3E10
• Applications: IHC
• Recommended Dilution: IHC 1:150
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 17-238 of human EDN3(NP_000105) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22.8 kDa
• Gene Name: endothelin 3
• Database Link:
  NP_000105
  Entrez Gene 1908 Human
  UniProt ID P14138
• Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
• Synonyms: ET-3; ET3; HSCR4; PPET3; WS4B

Reference Data

• Protein Families: Druggable Genome, Secreted Protein