TNFSF9 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4G5]

CAT#: TA813214AM

CD137L mouse monoclonal antibody,clone OTI4G5, Biotinylated

Product Images

Flow cytometric analysis of living 293T cells transfected with CD137L overexpression plasmid (RC211160), Red)/empty vector (PS100001, Blue) using anti-CD137L antibody (TA813214). Cells incubated with a non-specific antibody (Green) were used as isotype control (1:100).

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  Flow cytometric analysis of living Raji cells, using anti-CD137L antibody (TA813214, Red), compared to an isotype control (green), and a PBS control (blue) (1:100).

Specifications

Product Data

• Clone Name: OTI4G5
• Applications: FC
• Recommended Dilution: FLOW 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human CD137L (NP_003802) produced in HEK293T cell.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26.4 kDa
• Gene Name: tumor necrosis factor superfamily member 9
• Database Link:
  NP_003802
  Entrez Gene 8744 Human
  UniProt ID P41273
• Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [provided by RefSeq, Oct 2008]
• Synonyms: 4-1BB-L; CD137L; TNLG5A

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction