DDB1 Rabbit Polyclonal Antibody

CAT#: TA890041S

Rabbit polyclonal anti-DDB1 Antibody

Size: 30 ul 100 ul


 

USD 159.00

2 Days*

Size
    • 30 ul

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:500~1:1000
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human DDB1
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1.62mg/ml
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 126.8 kDa
Gene Name damage specific DNA binding protein 1
Background The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Synonyms DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
Reference Data
Protein Families Druggable Genome
Protein Pathways Nucleotide excision repair, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.