Aatf Rat Monoclonal Antibody [Clone ID: 1B2D8]

CAT#: TMPSKU_BIORAD_815

Aatf rat monoclonal antibody, clone 1B2D8, Purified

Specifications

Product Data

• Clone Name: 1B2D8
• Applications: IF, WB
• Reactivities: Human
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: A peptide comprising amino acids 1-39 of mouse AATF (apoptosis-antagonizing transcription factor)
• Specificity: AATF
• Formulation: Phosphate buffered saline containing 0.035% Sodium Azide (NaN3)30% Glycerol
  Label: Purified
  State: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant Purified IgG - liquid
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: +4°C, -20°C if preferred
• Stability: Shelf life: one year from despatch.
• Gene Name: apoptosis antagonizing transcription factor
• Database Link:
  UniProt ID Q9JKX4
• Background: Rat anti Mouse AATF antibody, clone 1B2D8 recognizes apoptosis-antagonizing transcription factor, also known as Rb-binding protein che-1.AATF was first identified as an RNA pol II – interacting factor (Fanciulli et al. 2000). AATF is a protein encoded by the AATF gene. AATF mediates cellular responses and promotes cell proliferation and survival by inducing autophagy, DNA repair, and cell cycle arrest and inhibiting apoptosis (Kumar et al. 2019). DNA damage leads to phosphorylation of AATF at tyrosine 366 by the MAP kinase-activated protein kinase 2 (MK2) (Höpker et al. 2012).Rat anti Mouse AATF antibody detects a band of 80 kDa.
• Synonyms: CHE-1; CHE1; DED