Human IL-1 beta ELISpot Set, 10 x 96-well (plates not included)

CAT#: EA101556

Human IL-1 beta ELISpot Set, 10 x 96-well (plates not included)

Specifications

Product Data

• Format: 10 x 96-well (plates not included)
• Assay Type: Enzyme-Linked ImmunoSpot (ELISpot)
• Assay Length: 3h after cell stimulation
• Signal: Colorimetric
• Specificity: Recognizes natural (pro and mature) human IL-1b
• Cross Reactivity: No cross reactivity with other human cytokines
• Components: ELISpot Sets include capture and detection antibodies, Streptavidin - Alkaline Phosphatase conjugated, BSA, BCIP/NTB, and blocking reagent.
• Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
• Gene Symbol: IL1B