EXOSC6 (NM_058219) Human 3' UTR Clone

CAT#: SC210743

3`UTR clone of exosome component 6 (EXOSC6) for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: EXOSC6
• Synonyms: EAP4; hMtr3p; MTR3; Mtr3p; p11
• ACCN: NM_058219
• Insert Size: 840
• Sequence Data:
  Insert Sequence

  >SC210743 3'UTR clone of NM_058219
  The sequence shown below is from the reference sequence of NM_058219. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  CGCCGCCCAGCCCTGAACCAGAAGCCTGAGCAACTACGGACGCAAGCCGAGGACCGTGCTGCCGCCGTCC
  ACGAAAAGACCCGCGCCATCGGCCTCCAGTTTGCGTCGAGAATTCCTGGAAGGGCCCTGATATGACTGTG
  GTTGGACTGACCTGACTGCCAGATGGTGGGACTTGGTCTGGAGCAGGGACTACTTGGAATGATAAAGGCA
  AAACTCAACAGCCCCTGGAGCTGCGCTTGTGGTGGAGCTGGACCCTGAAATTACCTGGACCTTTTTTTTA
  GAGACAGGGTTTCTTTCTGCAGTCTCAAACTCCTAGCCTTGATTGATCCTCCTGCCTTGGCCTCCCAAAG
  TGCTGGGACTACAGGTGCATGCAACCACACCTGGCTAATTTTCTTTTCTTCTTTCTTTCTTTTTTTTTTT
  TTTTTTTTTTTGATGGAGTCTTGTTCTGTTGCCCAGGCTGGAGTGCAATGGTGCAATCTTGGCTCACTGC
  AACCTCTGCCTCCTGGGTTCAATCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACAT
  GCCTCCATACCGGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTGGGCCAGGCTGTTCT
  CGAATGCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCAC
  TGTGCCCAGCTGAGTAAATTTCTTGATTGCACAGAATGTACGGTGATATTGGCGGACTTAAGGACATCGA
  ATTGTTTATCAGGAATAAAGTATTATGTGTGTTTTCTGCGGCCCTGGATAATGCTGTAGCATTCAGGGTC
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).

Reference Data

• RefSeq: NM_058219.2
• Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
• Locus ID: 118460