FADD (NM_003824) Human 3' UTR Clone

CAT#: SC211184

3`UTR clone of Fas (TNFRSF6)-associated via death domain (FADD) for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: FADD
• Synonyms: GIG3; MORT1
• ACCN: NM_003824
• Insert Size: 946
• Sequence Data:
  Insert Sequence

  >SC211184 3'UTR clone of NM_003824
  The sequence shown below is from the reference sequence of NM_003824. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  GGAACTCAGACGCATCTACCTCCGAAGCGTCCTGATGGGCCGCTGCTTTGCGCTGGTGGACCACAGGCAT
  CTACACAGCCTGGACTTTGGTTCTCTCCAGGAAGGTAGCCCAGCACTGTGAAGACCCAGCAGGAAGCCAG
  GCTGAGTGAGCCACAGACCACCTGCTTCTGAACTCAAGCTGCGTTTATTAATGCCTCTCCCGCACCAGGC
  CGGGCTTGGGCCCTGCACAGATATTTCCATTTCTTCCTCACTATGACACTGAGCAAGATCTTGTCTCCAC
  TAAATGAGCTCCTGCGGGAGTAGTTGGAAAGTTGGAACCGTGTCCAGCACAGAAGGAATCTGTGCAGATG
  AGCAGTCACACTGTTACTCCACAGCGGAGGAGACCAGCTCAGAGGCCCAGGAATCGGAGCGAAGCAGAGA
  GGTGGAGAACTGGGATTTGAACCCCCGCCATCCTTCACCAGAGCCCATGCTCAACCACTGTGGCGTTCTG
  CTGCCCCTGCAGTTGGCAGAAAGGATGTTTTGTCCCATTTCCTTGGAGGCCACCGGGACAGACCTGGACA
  CTAGGGTCAGGCGGGGTGCTGTGGTGGGGAGAGGCATGGCTGGGGTGGGGGTGGGGAGACCTGGTTGGCC
  GTGGTCCAGCTCTTGGCCCCTGTGTGAGTTGAGTCTCCTCTCTGAGACTGCTAAGTAGGGGCAGTGATGG
  TTGCCAGGACGAATTGAGATAATATCTGTGAGGTGCTGATGAGTGATTGACACACAGCACTCTCTAAATC
  TTCCTTGTGAGGATTATGGGTCCTGCAATTCTACAGTTTCTTACTGTTTTGTATCAAAATCACTATCTTT
  CTGATAACAGAATTGCCAAGGCAGCGGGATCTCGTATCTTTAAAAAGCAGTCCTCTTATTCCTAAGGTAA
  TCCTATTAAAACACAGCTTTACAACTTCCATACTAC
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).

Reference Data

• RefSeq: NM_003824.3
• Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
• Locus ID: 8772