Factor XI (F11) (NM_000128) Human 3' UTR Clone

CAT#: SC212199

3`UTR clone of coagulation factor XI (F11) for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: F11
• Synonyms: FXI; PTA
• ACCN: NM_000128
• Insert Size: 1089 bp
• Sequence Data:
  Insert Sequence

  >SC212199 3'UTR clone of NM_000128
  The sequence shown below is from the reference sequence of NM_000128. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  TCGAGTACGTGGACTGGATTCTGGAGAAAACTCAAGCAGTGTGAATGGGTTCCCAGGGGCCATTGGAGTC
  CCTGAAGGACCCAGGATTTGCTGGGAGAGGGTGTTGAGTTCACTGTGCCAGCATGCTTCCTCCACAGTAA
  CACGCTGAAGGGGCTTGGTGTTTGTAAGAAAATGCTAGAAGAAAACAAACTGTCACAAGTTGTTATGTCC
  AAAACTCCCGTTCTATGATCGTTGTAGTTTGTTTGAGCATTCAGTCTCTTTGTTTTTGATCACGCTTCTA
  TGGAGTCCAAGAATTACCATAAGGCAATATTTCTGAAGATTACTATATAGGCAGATATAGCAGAAAATAA
  CCAAGTAGTGGCAGTGGGGATCAGGCAGAAGAACTGGTAAAAGAAGCCACCATAAATAGATTTGTTCGAT
  GAAAGATGAAAACTGGAAGAAAGGAGAACAAAGACAGTCTTCACCATTTTGCAGGAATCTACACTCTGCC
  TATGTGAACACATTTCTTTTGTAAAGAAAGAAATTGATTGCATTTAATGGCAGATTTTCAGAATAGTCAG
  GAATTCTTGTCATTTCCATTTTAAAATATATATTAAAAAAAATCAGTTCGAGTAGACACGAGCTAAGAGT
  GAATGTGAAGATAACAGAATTTCTGTGTGGAAGAGGATTACAAGCAGCAATTTACCTGGAAGTGATACCT
  TAGGGGCAATCTTGAAGATACACTTTCCTGAAAAATGATTTGTGATGGATTGTATATTTATTTAAAATAT
  CTTGGGAGGGGAGGCTGATGGAGATAGGGAGCATGCTCAAACCTCCCTAAGACAAGCTGCTGCTGTGACT
  ATGGGCTCCCAAAGAGCTAGATCGTATATTTATTTGACAAAAATCACCATAGACTGCATCCATACTACAG
  AGAAAAAACAATTAGGGCGCAAATGGATAGTTACAGTAAAGTCTTCAGCAAGCAGCTGCCTGTATTCTAA
  GCACTGGGATTTTCTGTTTCGTGCAAATATTTATCTCATTATTGTTGTGATCTAGTTCAATAACCTAGAA
  TTTGAATTGTCACCACATAGCTTTCAATCTGTGCCAACA
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.

Reference Data

• RefSeq: NM_000128.3
• Summary: 'This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]'
• Locus ID: 2160