Activin Receptor Type IA (ACVR1) (NM_001105) Human 3' UTR Clone

CAT#: SC212415

3`UTR clone of activin A receptor type I (ACVR1) transcript variant 1 for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: ACVR1
• Synonyms: ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
• ACCN: NM_001105
• Insert Size: 1109 bp
• Sequence Data:
  Insert Sequence

  >SC212415 3'UTR clone of NM_001105
  The sequence shown below is from the reference sequence of NM_001105. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  CTCGACAAATTGAAAACTGACTGTTGACATTTTCATAGTGTCAAGAAGGAAGATTTGACGTTGTTGTCAT
  TGTCCAGCTGGGACCTAATGCTGGCCTGACTGGTTGTCAGAATGGAATCCATCTGTCTCCCTCCCCAAAT
  GGCTGCTTTGACAAGGCAGACGTCGTACCCAGCCATGTGTTGGGGAGACATCAAAACCACCCTAACCTCG
  CTCGATGACTGTGAACTGGGCATTTCACGAACTGTTCACACTGCAGAGACTAATGTTGGACAGACACTGT
  TGCAAAGGTAGGGACTGGAGGAACACAGAGAAATCCTAAAAGAGATCTGGGCATTAAGTCAGTGGCTTTG
  CATAGCTTTCACAAGTCTCCTAGACACTCCCCACGGGAAACTCAAGGAGGTGGTGAATTTTTAATCAGCA
  ATATTGCCTGTGCTTCTCTTCTTTATTGCACTAGGAATTCTTTGCATTCCTTACTTGCACTGTTACTCTT
  AATTTTAAAGACCCAACTTGCCAAAATGTTGGCTGCGTACTCCACTGGTCTGTCTTTGGATAATAGGAAT
  TCAATTTGGCAAAACAAAATGTAATGTCAGACTTTGCTGCATTTTACACATGTGCTGATGTTTACAATGA
  TGCCGAACATTAGGAATTGTTTATACACAACTTTGCAAATTATTTATTACTTGTGCACTTAGTAGTTTTT
  ACAAAACTGCTTTGTGCATATGTTAAAGCTTATTTTTATGTGGTCTTATGATTTTATTACAGAAATGTTT
  TTAACACTATACTCTAAAATGGACATTTTCTTTTATTATCAGTTAAAATCACATTTTAAGTGCTTCACAT
  TTGTATGTGTGTAGACTGTAACTTTTTTTCAGTTCATATGCAGAACGTATTTAGCCATTACCCACGTGAC
  ACCACCGAATATATTACTGATTTAGAAGCAAAGATTTCAGTAGAATTTTAGTCCTGAACGCTACGGGGAA
  AATGCATTTTCTTCAGAATTATCCATTACGTGCATTTAAACTCTGCCAGAAAAAAATAACTATTTTGTTT
  TAATCTACTTTTTGTATTTAGTAGTTATTTGTATAAATTAAATAAACTGTTTTCAAGTC
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.

Reference Data

• RefSeq: NM_001105.4
• Summary: 'Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]'
• Locus ID: 90