TGF beta 2 (TGFB2) (NM_003238) Human 3' UTR Clone
CAT#: SC220584
3`UTR clone of transforming growth factor beta 2 (TGFB2) transcript variant 2 for miRNA target validation
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Specifications
Product Data | |
Vector | pMirTarget |
Species | Human |
Transfection Reporter | RFP |
Assay Reporter | Luciferase |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Symbol | TGFB2 |
Synonyms | G-TSF; LDS4; TGF-beta2 |
ACCN | NM_003238 |
Insert Size | 3252 bp |
Sequence Data |
>SC220584 3'UTR clone of NM_003238
The sequence shown below is from the reference sequence of NM_003238. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC AAAGTCTTGCAAATGCAGCTAAAATTCTTGGAAAAGTGGCAAGACCAAAATGACAATGATGATGATAATG ATGATGACGACGACAACGATGATGCTTGTAACAAGAAAACATAAGAGAGCCTTGGTTCATCAGTGTTAAA AAATTTTTGAAAAGGCGGTACTAGTTCAGACACTTTGGAAGTTTGTGTTCTGTTTGTTAAAACTGGCATC TGACACAAAAAAAGTTGAAGGCCTTATTCTACATTTCACCTACTTTGTAAGTGAGAGAGACAAGAAGCAA ATTTTTTTTAAAGAAAAAAATAAACACTGGAAGAATTTATTAGTGTTAATTATGTGAACAACGACAACAA CAACAACAACAACAAACAGGAAAATCCCATTAAGTGGAGTTGCTGTACGTACCGTTCCTATCCCGCGCCT CACTTGATTTTTCTGTATTGCTATGCAATAGGCACCCTTCCCATTCTTACTCTTAGAGTTAACAGTGAGT TATTTATTGTGTGTTACTATATAATGAACGTTTCATTGCCCTTGGAAAATAAAACAGGTGTATAAAGTGG AGACCAAATACTTTGCCAGAAACTCATGGATGGCTTAAGGAACTTGAACTCAAACGAGCCAGAAAAAAAG AGGTCATATTAATGGGATGAAAACCCAAGTGAGTTATTATATGACCGAGAAAGTCTGCATTAAGATAAAG ACCCTGAAAACACATGTTATGTATCAGCTGCCTAAGGAAGCTTCTTGTAAGGTCCAAAAACTAAAAAGAC TGTTAATAAAAGAAACTTTCAGTCAGAATAAGTCTGTAAGTTTTTTTTTTTCTTTTTAATTGTAAATGGT TCTTTGTCAGTTTAGTAAACCAGTGAAATGTTGAAATGTTTTGACATGTACTGGTCAAACTTCAGACCTT AAAATATTGCTGTATAGCTATGCTATAGGTTTTTTCCTTTGTTTTGGTATATGTAACCATACCTATATTA TTAAAATAGATGGATATAGAAGCCAGCATAATTGAAAACACATCTGCAGATCTCTTTTGCAAACTATTAA ATCAAAACATTAACTACTTTATGTGTAATGTGTAAATTTTTACCATATTTTTTATATTCTGTAATAATGT CAACTATGATTTAGATTGACTTAAATTTGGGCTCTTTTTAATGATCACTCACAAATGTATGTTTCTTTTA GCTGGCCAGTACTTTTGAGTAAAGCCCCTATAGTTTGACTTGCACTACAAATGCATTTTTTTTTTAATAA CATTTGCCCTACTTGTGCTTTGTGTTTCTTTCATTATTATGACATAAGCTACCTGGGTCCACTTGTCTTT TCTTTTTTTTGTTTCACAGAAAAGATGGGTTCGAGTTCAGTGGTCTTCATCTTCCAAGCATCATTACTAA CCAAGTCAGACGTTAACAAATTTTTATGTTAGGAAAAGGAGGAATGTTATAGATACATAGAAAATTGAAG TAAAATGTTTTCATTTTAGCAAGGATTTAGGGTTCTAACTAAAACTCAGAATCTTTATTGAGTTAAGAAA AGTTTCTCTACCTTGGTTTAATCAATATTTTTGTAAAATCCTATTGTTATTACAAAGAGGACACTTCATA GGAAACATCTTTTTCTTTAGTCAGGTTTTTAATATTCAGGGGGAAATTGAAAGATATATATTTTAGTCGA TTTTTCAAAAGGGGAAAAAAGTCCAGGTCAGCATAAGTCATTTTGTGTATTTCACTGAAGTTATAAGGTT TTTATAAATGTTCTTTGAAGGGGAAAAGGCACAAGCCAATTTTTCCTATGATCAAAAAATTCTTTCTTTC CTCTGAGTGAGAGTTATCTATATCTGAGGCTAAAGTTTACCTTGCTTTAATAAATAATTTGCCACATCAT TGCAGAAGAGGTATCCTCATGCTGGGGTTAATAGAATATGTCAGTTTATCACTTGTCGCTTATTTAGCTT TAAAATAAAAATTAATAGGCAAAGCAATGGAATATTTGCAGTTTCACCTAAAGAGCAGCATAAGGAGGCG GGAATCCAAAGTGAAGTTGTTTGATATGGTCTACTTCTTTTTTGGAATTTCCTGACCATTAATTAAAGAA TTGGATTTGCAAGTTTGAAAACTGGAAAAGCAAGAGATGGGATGCCATAATAGTAAACAGCCCTTGTGTT GGATGTAACCCAATCCCAGATTTGAGTGTGTGTTGATTATTTTTTTGTCTTCCACTTTTCTATTATGTGT AAATCACTTTTATTTCTGCAGACATTTTCCTCTCAGATAGGATGACATTTTGTTTTGTATTATTTTGTCT TTCCTCATGAATGCACTGATAATATTTTAAATGCTCTATTTTAAGATCTCTTGAATCTGTTTTTTTTTTT TTTAATTTGGGGGTTCTGTAAGGTCTTTATTTCCCATAAGTAAATATTGCCATGGGAGGGGGGTGGAGGT GGCAAGGAAGGGGTGAAGTGCTAGTATGCAAGTGGGCAGCAATTATTTTTGTGTTAATCAGCAGTACAAT TTGATCGTTGGCATGGTTAAAAAATGGAATATAAGATTAGCTGTTTTGTATTTTGATGACCAATTACGCT GTATTTTAACACGATGTATGTCTGTTTTTGTGGTGCTCTAGTGGTAAATAAATTATTTCGATGATATGTG GATGTCTTTTTCCTATCAGTACCATCATCGAGTCTAGAAAACACCTGTGATGCAATAAGACTATCTCAAG CTGGAAAAGTCATACCACCTTTCCGATTGCCCTCTGTGCTTTCTCCCTTAAGGACAGTCACTTCAGAAGT CATGCTTTAAAGCACAAGAGTCAGGCCATATCCATCAAGGATAGAAGAAATCCCTGTGCCGTCTTTTTAT TCCCTTATTTATTGCTATTTGGTAATTGTTTGAGATTTAGTTTCCATCCAGCTTGACTGCCGACCAGAAA AAATGCAGAGAGATGTTTGCACCATGCTTTGGCTTTCTGGTTCTATGTTCTGCCAACGCCAGGGCCAAAA GAACTGGTCTAGACAGTATCCCCTGTAGCCCCATAACTTGGATAGTTGCTGAGCCAGCCAGATATAACAA GAGCCACGTGCTTTCTGGGGTTGGTTGTTTGGGATCAGCTACTTGCCTGTCAGTTTCACTGGTACCACTG CACCACAAACAAAAAAACCCACCCTATTTCCTCCAATTTTTTTGGCTGCTACCTACAAGACCAGACTCCT CAAACGAGTTGCCAATCTCTTAATAAATAGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
Reference Data | |
RefSeq | NM_003238.2 |
Summary | 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]' |
Locus ID | 7042 |
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