Bcs1l (NM_025784) Mouse Untagged Clone

CAT#: MC202866

Bcs1l (untagged) - Mouse BCS1-like (yeast) (Bcs1l), nuclear gene encoding mitochondrial protein, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Bcs1l
• Synonyms: 9130022O19Rik
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC019781 sequence for NM_025784
  GTTCCTGGAAGCGCGAGCAGTTCTGCTACAATCCATCCCTCGGTTTTGACAGTGCCTCAGAGCCTATAAG CATCTGTGCTGCTTCTTTTCAAGATGCCATTTTCAGACTTTGTTCTGGCCCTTAAAGACAATCCCTACTT TGGGGCTGGATTTGGGCTGGTAGGTGTGGGTACGGCTCTGGCTATGGCCCGGAAAGGAGCCCAGTTGGGT CTAGTGGCATTCCGGCGCCATTACATGATCACACTGGAAGTCCCTGCCAGAGACAGAAGCTATGCCTGGT TGCTTAGCTGGCTTACCCGACACAGCACCCGCACTCAGCACCTCAGTGTTGAAACCTCATACCTTCAGCA TGAAAGTGGCCGGATCTCCACCAAGTTTGAATTTATCCCCAGCCCTGGAAACCACTTCATTTGGTATCAG GGAAAATGGATCCGGGTAGAACGAAACCGAGACATGCAGATGGTAGACTTGCAAACAGGGACTCCTTGGG AATCTGTCACCTTCACGGCCCTGGGCACTGACCGAAAGGTTTTCTTCAACATCCTGGAAGAAGCTCGAGC ACTGGCCCTGCAGCAGGAGGAAGGGAAGACTGTGATGTACACAGCTGTGGGGTCTGAATGGCGTACCTTT GGTTATCCGCGCCGACGTCGGCCACTGGATTCTGTAGTCCTACAGCAGGGTCTGGCTGACCGAATTGTCA AAGATATCCGGGAATTTATTGATAACCCCAAGTGGTACATTGACAGAGGCATTCCCTACAGACGTGGCTA CCTTCTTTATGGGCCCCCTGGTTGTGGAAAGAGCAGTTTTATAACAGCCCTGGCTGGAGAACTGGAACAC AGCATCTGCCTGCTCAGCCTCACAGACTCTAGCCTCTCAGATGACCGGCTCAACCATCTACTGAGTGTAG CACCACAGCAGAGCTTGGTGCTCCTGGAAGATGTGGATGCTGCTTTTCTCAGTAGAGACTTGGCTGTGGA GAACCCTATAAAGTACCAAGGACTAGGCCGCCTCACCTTCAGTGGACTGCTTAATGCTTTGGATGGTGTA GCCTCCACTGAAGCACGAATTGTGTTCATGACCACCAACTACATTGACAGGCTGGATCCTGCCCTCATAC GTCCCGGGCGAGTAGATCTGAAGGAGTATGTGGGCTACTGCTCACACTGGCAGCTGACCCAGATGTTCCA GAGGTTCTATCCAGGGCAAGCACCTTCTTTGGCTGAGAACTTTGCTGAACATGTCCTTAAAGCTACATCT GAGATTAGTCCTGCCCAGGTGCAAGGCTACTTCATGCTGTATAAAAATGACCCCATGGGGGCTGTTCACA ACATTGAATCTCTGAGGTGACCCACCAGGCCATGATCTGCTCTCAAAAATTCCATAAACACCTGTCACAC TAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_025784
• ORF Size: 1257 bp
• Insert Size: 1257
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC019781, AAH19781
• RefSeq Size: 1416
• RefSeq ORF: 1257
• Locus ID: 66821
• Gene Summary: The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
  Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note:.