Cops5 (NM_013715) Mouse Untagged Clone

CAT#: MC209743

Cops5 (untagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) (Cops5), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Cops5
• Synonyms: AI303502; CSN5; Jab1; Mov34; Sgn5
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC209743 representing NM_013715
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCAGCTTCCGGGAGTGGTATGGCCCAGAAAACCTGGGAATTGGCCAACAACATGCAGGAAGCGCAGA
  GTATCGATGAAATCTACAAATATGACAAAAAACAACAACAAGAAATCCTGGCGGCGAAACCCTGGACTAA
  GGATCACCACTACTTTAAATACTGCAAAATCTCAGCATTGGCTCTACTGAAAATGGTGATGCATGCCAGG
  TCAGGAGGCAACTTGGAAGTGATGGGTTTGATGCTCGGGAAAGTCGACGGCGAGACCATGATCATCATGG
  ACAGTTTCGCTTTGCCTGTAGAGGGCACAGAAACTCGAGTAAATGCTCAAGCTGCTGCGTATGAGTATAT
  GGCTGCATACATAGAAAATGCCAAACAGGTTGGCCGCCTTGAGAATGCAATCGGTTGGTATCATAGCCAC
  CCTGGTTATGGCTGCTGGCTCTCCGGGATTGATGTTAGTACACAGATGCTGAACCAGCAGTTTCAAGAAC
  CATTTGTAGCAGTGGTGATTGATCCAACCAGAACAATCTCTGCAGGAAAAGTGAATCTTGGCGCCTTTAG
  GACATATCCAAAGGGCTACAAACCTCCTGATGAAGGACCTTCTGAGTACCAGACTATCCCACTTAATAAA
  ATAGAAGATTTTGGCGTGCACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCATCTTTGG
  ATCGTAAACTACTTGAGCTTTTGTGGAATAAATACTGGGTGAATACCCTGAGTTCCTCTAGCTTGCTTAC
  TAATGCAGACTACACCACAGGCCAGGTGTTTGATTTGTCTGAGAAGTTAGAGCAGTCGGAAGCCCAACTG
  GGACGTGGCAGTTTCATGTTGGGCTTAGAAACACATGACCGCAAGTCGGAAGACAAACTTGCCAAAGCTA
  CTAGAGACAGCTGTAAAACCACCATAGAAGCCATCCATGGACTGATGTCTCAGGTTATTAAGGATAAACT
  GTTTAATCAGATTAACGTTGCTTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_013715
• ORF Size: 1005 bp
• Insert Size: 1005
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_013715.2, NP_038743.1
• RefSeq Size: 1731
• RefSeq ORF: 1005
• Locus ID: 26754
• Gene Summary: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longer isoform (1).