Azin2 (NM_172875) Mouse Untagged Clone
CAT#: MC216202
Adc (untagged) - Mouse arginine decarboxylase (Adc), (10ug)
"NM_172875" in other vectors (4)
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Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Symbol | Azin2 |
Synonyms | 4933429I20Rik; Adc; Azi2; B930082O19; ODC-p; Odcp |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC216202 representing NM_172875
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTGGCTATCTGAGTGAATCGGACTTTGTGATGGTGGAGGAGGGCTTCAGCACCCGGGATCTGCTGG AGGAGCTCACTCTGGGGGCCTCCCAGGCCACCTCGGGCAAGGTGGCTGCCTTCTTCGTGGCCGACCTGGG TGCTGTAGTGAGGAAGCACTTCTGCTTTCTGAAGCACCTGCCTCGAGTCCGGCCTTTTTATGCTGTCGGG TGCAACAGCAGCCTGGGCGTGCTGAAGGTTCTAGCCGAACTGGGGCTGGGCTTCAGCTGTGCCAACAAGG CAGAGATGGAGTTGGTCCAGCACATTGGTGTCCCTGCCAGTAAGATCATCTGTGCCAACCCCTGTAAGCA AGTTGCACAGATCAAGTATGCTGCCAAGCACGGGGTGAGGCTGCTGAGCTTCGACAATGAAGTGGAGCTG GCCAAGGTGGTCAAGAGCCACCCCAGTGCCAAGATGGTTCTGTGCATTGCTACCCAGGACTCCCACTCTC TGAATCACCTGAGCCTGAGGTTTGGGGCGTCGCTGAAATCCTGCAGACATCTGCTCGAGAACGCCAAGAA GAGCCACGTGGAGGTGGTGGGTGTGAGTTTTCACATTGGCAGTGGCTGTCCTGACCCTCAGGCCTATGCC CAGTCCATCGCGGATGCTAGGCTGGTGTTTCAGATGGGCGAGGAGCTGGGCCACACGATGAACATCCTGG ACCTTGGCGGCGGCTTTCCTGGCTTAGAGGGAGCCAAAGTGAGATTTGAAGAGATGGCCTCAGTAATTAA CTCAGCCTTGGACCTGTACTTCCCTGAGGGCTGCGGTGTGGACATCCTTGCTGAGCTGGGACGCTACTAC GTGACGTCTGCCTTCACTGTGGCTGTCAGCATCGTCGCCAAGAGGGAGGTTCTGGACCAGGCCAGCAGGG AAGAGCAAACCGGCGCAGCCCCTAAGAGCATCGTGTACTACCTTGATGAGGGCGTTTATGGGGTCTTCAA CTCAGTCCTGTTTGACAACACCTGCCCCACCCCCGCCCTGCAGAAGAAACCATCTGCGGATCAACCACTG TACAGCAGCAGCCTGTGGGGCCCAGCAGTTGAAGGCTGCGACTGTGTGGCTGAGGGCCTGTGGCTGCCGC AACTACAAGTAGGGGACTGGCTGGTCTTTGACAACATGGGTGCTTACACCGTGGACACAAAGTCCCTCCT TGGGGGGACCCAGGCCCGCAGAGTCACTTATGCCATGTCCCGGCTAGCCTGGGAAGCGCTTCGAGGGCAG CTGTTGCCTGCAGAAGAAGACCAGGACGCCGAGGGTGTGTGCAAACCTCTGTCCTGCGGCTGGGAGATCA CAGACACCTTGTGTGTGGGCCCTGTCTTCACCCCAGCAAGCATCATGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_172875 |
ORF Size | 1380 bp |
Insert Size | 1380 |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Reference Data | |
RefSeq | NM_172875.4, NP_766463.1 |
RefSeq Size | 2084 |
RefSeq ORF | 1380 |
Locus ID | 242669 |
Gene Summary | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MR222916 | Adc (Myc-DDK-tagged) - Mouse arginine decarboxylase (Adc) |
USD 430.00 |
|
MG222916 | Adc (GFP-tagged) - Mouse arginine decarboxylase (Adc), (10ug) |
USD 470.00 |
|
MR222916L3 | Lenti ORF clone of Adc (Myc-DDK-tagged) - Mouse arginine decarboxylase (Adc) |
USD 630.00 |
|
MR222916L4 | Lenti ORF clone of Adc (mGFP-tagged) - Mouse arginine decarboxylase (Adc) |
USD 630.00 |
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