Bmp3 (NM_173404) Mouse Untagged Clone

CAT#: MC216355

Bmp3 (untagged) - Mouse bone morphogenetic protein 3 (Bmp3), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Bmp3
• Synonyms: 9530029I04Rik
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC216355 representing NM_173404
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCGGGGCGCGCGGGCTGCTCTGTCTATGGCTAGGTTACTTCTGCCTGAACCTGGCACAGGGACAGA
  GACCAAACTTGCACCTCCCGGGACTCCGTGAGACTGAGCCAAGCGACCGCGCGACAGGTGGTAGCCCGAG
  TCCGGACCTGAGGCCGCACGACAAGGTGTCGGAGCATATGCTGTGGCTCTATGACAGGTACAGCGGCAGC
  AGTAGAGTCCAGGCTACCCGGACACCGGGCTCGCAGCTCCCGGGTCCTCAGCCCCTGCGCGGTGGTAACA
  CGGTCCGCAGCTTCAGAGCCGCAGCCGCAGGAACTCCTCAAACGAAGGGGTTACACACCTTCAATCTGAC
  TTCTCTAACCAAGTCGGAGAACATTTTGTCAGCCACACTGTATTTCTACGTTGGAGAATTAGTGAACATC
  AGCTTGAGCTGTCCAGAACCCCAAGGATGCTCCCATCACACTCAGAGACAACACATCCAGATAGACCTCT
  CTGCATGGATCCTCAAATCCAACCAAAGCCAGCTCTTGGGTCATCTGTCTGTAGATGTGGTCAGACCTTA
  TAGAGACAGCGTGTCTTGGCTGTCAAAAGACATCACTCAGCTCTTAAGAAAGGCCAAGCAAAATGAAGAG
  TTTCTCATAGGGTTTAACATTACCTCCAGAGCACACGAGCTACCCAAGAGGATGCTGTTTTTCCCGGAAC
  CTTATATCTTGGTATACGCCAACGATGCTGCCATTTCTGAGCCAGAAAGCGTGGTATCCAGCTTACAGAG
  ACACCGAGATTTCACAGCGGGAACTGGGCCCAGACTGGATAGCCACGTCAGAGAAGCCCTCTCGGTTGAG
  AGGAGGAAGAAGCGCTCTACTGGGATCTTGCTGCCCTTGCAGAACAATGAGCTACCTGGGGCAGAGTATC
  AGTACAAGGAGGAGGGAGCGTGGGAGGAGAGAAAGCCTTATAAGAGCCTTCAGACTCAGCCCCCTGAGAA
  GAGTAGGAACAAAAAGAAACAGAGGAAAGGGTCCCATCAGAAGGGACAGACGCTGCAATTTGATGAGCAG
  ACCCTGAAGAAGGCAAGGCGAAAGCAGTGGGTCGAACCTCGGAACTGTGCCAGGAGGTACCTTAAAGTGG
  ACTTTGCTGATATCGGCTGGAGCGAATGGATTATCTCTCCCAAGTCATTTGATGCTTTCTACTGCTCTGG
  AGCCTGCCAGTTCCCCATGCCAAAGTCTTTGAAACCATCAAATCACGCCACCATCCAGAGCATAGTGCGA
  GCGGTGGGGGTCGTCTCCGGGATTCCCGAGCCTTGCTGTGTGCCGGAAAAGATGTCCTCACTCAGCATCT
  TGTTCTTTGATGAAAACAAGAATGTAGTGCTCAAAGTCTACCCTAACATGACAGTCGACTCCTGTGCTTG
  TAGATAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_173404
• ORF Size: 1407 bp
• Insert Size: 1407
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_173404.5, NP_775580.1
• RefSeq Size: 6229
• RefSeq ORF: 1407
• Locus ID: 110075
• Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
  Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.