Kpna3 (NM_008466) Mouse Untagged Clone

CAT#: MC217424

Kpna3 (untagged) - Mouse karyopherin (importin) alpha 3 (Kpna3), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Kpna3
• Synonyms: IPOA4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC217424 representing NM_008466
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCGAGAACCCCGGCTTGGAGAACCACCGCATCAAGAGCTTCAAGAACAAGGGCCGCGATGTGGAGA
  CGATGCGAAGACACAGAAATGAAGTGACAGTTGAACTCCGGAAGAACAAAAGAGACGAACACTTACTGAA
  AAAGAGAAATGTTCCCCAAGAAGAAAGCTTAGAAGATTCAGATGTTGATGCTGATTTTAAAGCACAAAAT
  GTAACACTAGAAGCTATATTACAGAATGCCACAAGTGATAATCCTGTAGTCCAGTTGAGTGCTGTGCAGG
  CAGCAAGGAAACTATTATCCAGTGACAGAAATCCACCAATTGATGACCTAATAAAATCTGGGATTTTACC
  AATTCTAGTCAAATGTCTAGAAAGAGATGATAATCCTTCATTACAGTTTGAAGCTGCTTGGGCACTAACT
  AATATAGCATCGGGAACTTCTGCACAGACTCAAGCTGTTGTACAGTCTAATGCAGTACCACTTTTTCTGC
  GACTCCTCCATTCCCCACATCAGAATGTTTGTGAACAAGCGGTGTGGGCTTTGGGAAACATTATAGGTGA
  TGGTCCTCAATGTAGAGATTATGTCATATCACTGGGAGTTGTCAAACCTCTTCTGTCCTTCATCAATCCC
  TCCATTCCCATCACCTTCCTTCGGAACGTCACATGGGTCATTGTCAATCTCTGCAGGAATAAAGACCCCC
  CACCGCCTATGGAGACAGTTCAGGAGATTTTGCCAGCTTTGTGTGTGCTCATCTACCATACGGACATAAA
  TATTCTTGTAGACACTGTTTGGGCGCTGTCATACTTGACAGACGGGGGAAATGAGCAAATACAGATGGTT
  ATTGATTCAGGGGTTGTACCCTTCCTCGTACCCCTTCTGAGCCACCAGGAAGTCAAAGTTCAAACTGCAG
  CACTCAGAGCGGTTGGGAACATAGTGACTGGCACTGATGAGCAGACCCAGGTGGTTCTCAACTGTGATGT
  CCTGTCCCACTTCCCAAACCTCTTGTCACACCCAAAAGAGAAAATAAATAAGGAAGCAGTATGGTTCCTT
  TCCAATATAACAGCAGGCAATCAGCAGCAAGTTCAAGCTGTAATAGATGCTGGGTTAATCCCTATGATTA
  TTCATCAGCTCGCTAAGGGGGACTTTGGAACACAAAAGGAAGCTGCTTGGGCAATTAGCAACTTAACGAT
  AAGTGGCAGAAAAGATCAAGTTGAATACCTTGTACAGCAGAACGTAATACCACCATTCTGTAACTTACTG
  TCAGTAAAAGATTCTCAAGTGGTGCAGGTGGTTCTAGATGGTCTTAAAAACATCCTGATAATGGCTGGTG
  ATGAAGCAAGCACAATAGCTGAGATCATAGAAGAGTGTGGAGGTTTGGAGAAAATTGAAGTTTTGCAGCA
  ACATGAAAATGAAGACATATATAAATTAGCATTTGAAATCATAGATCAATATTTCTCTGGTGATGATATT
  GATGAAGATCCTAGCCTCATTCCAGAAGCAACACAAGGAGGTACTTACAATTTTGACCCAACAGCCAACC
  TTCAAACAAAAGAATTTAATTTCTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_008466
• ORF Size: 1566 bp
• Insert Size: 1566
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_008466.5, NP_032492.1
• RefSeq Size: 4167
• RefSeq ORF: 1566
• Locus ID: 16648
• Gene Summary: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. [UniProtKB/Swiss-Prot Function]