Cd22 (NM_001043317) Mouse Untagged Clone

CAT#: MC222250

Cd22 (untagged) - Mouse CD22 antigen (Cd22), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Cd22
• Synonyms: A530093D23; Lyb-8; Lyb8
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC222250 representing NM_001043317
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCGCGTCCATTACCTGTGGCTCCTCTTGATCCTAGGACACGTGGCTTCGGCTCGGTACAGCTCAGCAA
  ATGATTGGACCGTTGACCATCCCCAAACCCTCTTTGCCTGGGAGGGAGCCTGCATCAGGATTCCTTGCAA
  GTACAAAACTCCACTACCCAAGGCACGTCTGGACAACATCCTCCTTTTTCAGAACTATGAGTTTGACAAG
  GCCACCAAGAAATTCACAGGAACTGTCCTGTACAACGCCACAAAGACTGAGAAGGACCCAGAGTCTGAGC
  TGTACCTTTCTAAGCAAGGGAGAGTAACATTTCTGGGGAACAGAATAGACAATTGTACCCTGAAAATCCA
  CCCGATACGTGCCAATGACAGTGGGAATCTGGGGTTGAGGATGACCGCAGGGACTGAACGATGGATGGAG
  CCCATTCACCTCAATGTCTCGGAGAAACCGTTCCAACCTTACATCCAGATGCCATCAGAAATCCGGGAAT
  CCCAAAGTGTCACTCTGACCTGTGGACTGAATTTCTCCTGCTTTGGGTATGACATCCTCTTGAAGTGGTT
  CCTAGAAGATTCTGAGATCACCTCCATCACCTCTTCTGTCACCTCCATCACCTCTTCTGTCACCTCCTCC
  ATTAAGAATGTCTATACAGAGAGCAAGCTCACCTTCCAACCAAAGTGGACGGACCACGGAAAGAGTGTGA
  AGTGCCAAGTCCAGCACTCCTCCAAAGTGCTCTCAGAGCGCACTGTGCGTCTGGATGTTAAGTATACCCC
  GAAGCTGGAGATCAAGGTCAATCCCACAGAGGTGGAAAAGAACAATTCTGTGACCATGACATGCCGGGTT
  AACAGCAGCAACCCGAAACTCAGGACCGTGGCGGTGTCTTGGTTCAAGGATGGGCGCCCCCTAGAGGATC
  AGGAACTGGAACAGGAACAACAGATGTCCAAGCTAATTCTGCATTCAGTGACCAAGGACATGAGAGGGAA
  ATACCGGTGCCAGGCTTCCAACGACATAGGCCCAGGAGAGTCGGAAGAAGTGGAACTCACGGTGCACTAT
  GCTCCAGAACCCTCCAGGGTTCACATCTACCCTTCCCCCGCTGAAGAGGGACAGTCAGTAGAGCTGATTT
  GTGAGTCACTGGCCAGTCCAAGTGCAACAAACTACACCTGGTATCACAACAGGAAACCTATACCTGGAGA
  CACCCAAGAGAAGCTCCGCATCCCTAAAGTCTCCCCGTGGCATGCTGGGAATTACTCTTGCTTGGCAGAG
  AACCGTCTGGGTCATGGAAAGATAGACCAGGAAGCTAAGCTGGATGTCCATTATGCTCCCAAGGCGGTGA
  CCACAGTGATTCAGAGCTTCACACCAATCCTGGAAGGAGACAGTGTGACCCTGGTCTGTAGGTACAACTC
  CAGCAATCCAGACGTCACCTCCTACAGATGGAACCCTCAAGGTTCTGGGAGTGTGCTCAAACCCGGAGTG
  CTGAGGATTCAGAAAGTGACATGGGATTCCATGCCTGTCAGCTGTGCTGCCTGCAACCACAAGTGTTCGT
  GGGCCCTCCCTGTCATCCTGAATGTCCACTACGCCCCCAGAGACGTGAAGGTACTGAAGGTAAGCCCCGC
  ATCAGAGATCCGCGCTGGGCAGCGTGTCCTCCTCCAATGCGACTTCGCAGAGAGCAACCCGGCAGAGGTC
  CGCTTCTTCTGGAAGAAGAATGGGAGTCTCGTGCAGGAAGGGAGGTACCTGAGCTTCGGCTCCGTCTCCC
  CAGAAGATTCTGGAAATTATAACTGCATGGTCAACAACTCCATCGGAGAGACCTTGTCACAGGCCTGGAA
  CCTCCAAGTGCTGTATGCTCCTCGGAGGCTGCGTGTGTCCATCAGCCCTGGGGACCATGTGATGGAGGGG
  AAGAAGGCCACCTTGTCCTGTGAGAGTGATGCCAATCCGCCCATCTCACAGTACACCTGGTTTGACTCCA
  GTGGCCAAGACCTCCACTCCTCAGGCCAGAAACTGAGACTGGAACCCCTGGAGGTCCAACACACGGGTTC
  CTACCGCTGCAAAGGGACCAATGGGATAGGCACAGGAGAGTCACCACCCAGCACCCTCACTGTCTACTAC
  AGTCCAGAGACCATCGGCAAGCGGGTCGCCTTGGGACTAGGCTTCTGCCTGACTATCTGCATCCTGGCCA
  TCTGGGGGATGAAAATCCAGAAAAAATGGAAGCAAAACCGCAGCCAGCAGGGGCTTCAGGAAAATTCCAG
  TGGCCAGAGCTTTTTTGTGAGGAACAAAAAGGCTAGGAGGACCCCTCTCTCAGAAGGCCCCCAATCCCAG
  GGATGCTACAATCCGGCAATGGATGACACCGTTAGTTATGCCATCTTGCGCTTTCCAGAGAGTGACACGC
  ACAACACTGGAGATGCAGGGACCCCAGCAACACAGGCTCCTCCTCCAAACAACAGCGACTCGGTCACTTA
  CTCGGTGATACAGAAGCGGCCTATGGGGGATTATGAGAATGTGAATCCGAGCTGCCCGGAGGATGAGAGC
  ATCCATTACTCAGAGCTGGTTCAGTTTGGGGCTGGTAAGCGGCCCCAGGCAAAGGAAGACGTAGACTATG
  TGACCCTCAAGCACTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001043317
• ORF Size: 2607 bp
• Insert Size: 2607
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_001043317.2, NP_001036782.1
• RefSeq Size: 4097
• RefSeq ORF: 2607
• Locus ID: 12483
• Gene Summary: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer protein-coding transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.