Xpc (NM_009531) Mouse Untagged Clone

CAT#: MC222687

Xpc (untagged) - Mouse xeroderma pigmentosum, complementation group C (Xpc), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Xpc
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC222687 representing NM_009531
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCCCCAAAGCGCACCGCAGACGGAAGGCGGCGGAAGCGGGGCCAGAAAACCGAGGACAACAAAGTAG
  CCCGGCACGAGGAGAGCGTTGCGGATGACTTTGAAGATGAGAAGCAGAAACCCCGAAGGAAGAGCTCTTT
  CCCGAAAGTCTCTCAAGGAAAGAGGAAGAGGGGCTGCAGTGATCCAGGGGACCCCACAAATGGTGCAGCA
  AAAAAGAAAGTGGCCAAAGCCACTGCTAAATCCAAGAATCTCAAGGTTCTGAAGGAGGAAGCACTCAGCG
  ACGGGGATGACTTCCGGGACTCACCAGCTGACTGCAAGAAGGCAAAGAAACACCCAAAAAGCAAGGTGGT
  GGACCAAGGCACTGATGAAGATGACAGTGAGGATGACTGGGAGGAGGTGGAAGAGCTTACTGAACCTGTG
  CTGGACATGGGAGAAAATTCTGCCACCTCACCGTCTGACATGCCTGTGAAGGCGGTGGAGATTGAAATTG
  AAACACCACAGCAGGCGAAAGAACGGGAAAGAAGTGAGAAGATAAAGATGGAGTTTGAGACATACCTGCG
  GAGGATGATGAAGCGTTTCAATAAAGAAGTACAGGAGAACATGCACAAGGTTCACCTGCTGTGCCTGCTG
  GCCAGTGGCTTCTATCGAAATAGCATCTGCCGACAGCCAGATCTGCTGGCCATTGGCCTCTCCATCATTC
  CAATTCGCTTTACCAAGGTGCCACTTCAAGATAGGGATGCCTACTACCTTTCAAACCTGGTAAAGTGGTT
  CATCGGAACCTTCACTGTCAACGCTGACCTTTCAGCCAGCGAGCAGGACGACCTGCAGACCACCTTGGAA
  AGGAGGATTGCCATTTACTCTGCGAGGGATAATGAAGAGTTGGTCCATATATTTCTTCTGATTCTTCGGG
  CTCTGCAGCTGCTCACCCGGCTGGTCTTGTCTCTGCAGCCCATTCCACTGAAGTCAGCTGTGACAAAGGG
  GAGGAAATCTTCCAAGGAGACATCTGTAGAGGGTCCTGGAGGTTCTTCAGAACTCTCTAGTAACAGTCCA
  GAAAGCCACAACAAACCTACGACCAGCAGGAGAATCAAAGAAGAAGAAACCTTGTCTGAGGGCAGAGGCA
  AAGCAACCGCCAGGGGGAAGAGAGGCACAGGCACTGCGGGCAGCAGGCAGCGGAGGAAGCCCTCTTGCAG
  CGAGGGAGAGGAGGCCGAGCAGAAAGTCCAGGGCCGTCCACATGCCCGGAAGCGGCGTGTGGCTGCCAAG
  GTGTCATACAAAGAGGAGAGTGAGAGCGATGGGGCAGGCAGCGGCTCTGACTTTGAACCGTCCAGTGGGG
  AGGGCCAGCATTCCTCTGATGAGGATTGTGAGCCTGGCCCTCGCAAGCAGAAGAGGGCCTCAGCTCCTCA
  GAGGACAAAGGCTGGGTCTAAGAGTGCTTCCAAGACCCAACGCGGAAGCCAGTGTGAGCCGTCAAGCTTT
  CCGGAGGCGTCTTCAAGCTCTTCAGGCTGTAAGAGAGGCAAGAAGGTTTCCAGTGGTGCTGAAGAGATGG
  CAGATAGGAAACCTGCTGGTGTAGACCAGTGGCTGGAGGTGTACTGTGAGCCACAGGCAAAGTGGGTGTG
  TGTGGACTGTGTACATGGTGTGGTGGGCCAGCCTGTGGCCTGTTACAAATATGCCACCAAACCCATGACC
  TATGTTGTAGGCATTGACAGTGATGGCTGGGTCCGAGATGTTACTCAGAGGTATGACCCAGCCTGGATGA
  CCGCAACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGGGCTGAGACCTTGAGACCCTATCGGAGCCTACT
  TACGGAGAGGGAGAAGAAGGAAGACCAGGAGTTTCAGGCGAAGCACCTGGACCAGCCTTTGCCCACCTCC
  ATCAGCACATACAAGAACCACCCTCTGTATGCCCTGAAGCGCCACCTCTTGAAATTCCAGGCTATCTACC
  CTGAGACAGCTGCGGTGCTCGGGTATTGTCGTGGAGAAGCAGTCTATTCCAGGGATTGCGTGCATACCTT
  GCACTCCAGGGACACATGGCTGAAGCAAGCAAGAGTGGTGCGGCTTGGAGAAGTGCCCTATAAGATGGTG
  AAAGGCTTCTCTAACCGTGCCCGGAAAGCCCGGCTCTCGGAGCCCCAGCTGCATGACCACAACGACTTGG
  GCCTCTATGGTCACTGGCAGACGGAAGAGTATCAGCCTCCTATAGCTGTCGATGGGAAGGTGCCTCGGAA
  TGAGTTTGGGAACGTGTACCTCTTCCTGCCCAGCATGATGCCCGTCGGCTGTGTCCAGATGACCCTGCCT
  AACCTGAACCGGGTGGCACGCAAGCTGGGCATCGACTGCGTGCAGGCCATCACTGGCTTCGATTTCCATG
  GAGGCTATTGCCATCCAGTAACTGATGGCTACATTGTCTGTGAGGAATTCAGAGACGTGCTGCTGGCTGC
  TTGGGAGAATGAACAGGCCATCATTGAAAAGAAGGAGAAGGAGAAAAAGGAAAAGCGGGCGCTGGGGAAC
  TGGAAGCTGCTGGTCAGAGGACTCCTCATCAGAGAGAGGCTGAAACTCCGCTATGGGGCCAAGAGCGAGG
  CAGCAGCTCCCCATGCTGCTGGAGGCGGACTCTCTTCTGATGAAGAGGAAGGGACCAGTTCACAAGCAGA
  AGCAGCCAGAGTCCTGGCTGCCTCCTGGCCACAGAACCGAGAGGATCCAGAACAGAAGTCCGAGTACACT
  AAGATGACTCGGAAGAGGCGGGCGGCAGAGGCTTCCCACCTCTTTCCGTTTGAGAAGCTGTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_009531
• ORF Size: 2793 bp
• Insert Size: 2793
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_009531.2, NP_033557.2
• RefSeq Size: 3634
• RefSeq ORF: 2793
• Locus ID: 22591
• Gene Summary: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by Rad23b and Rad23a. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. [UniProtKB/Swiss-Prot Function]