Nrxn1 (NM_020252) Mouse Untagged Clone

CAT#: MC224615

Nrxn1 (untagged) - Mouse neurexin I (Nrxn1), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Nrxn1
• Synonyms: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC224615 representing NM_020252
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGACGGCGCTGGTCCAGCGCGGGGGCTGCTGTCTCCTCTGCCTGTCGCTGCTGCTGCTGGGCTGCT
  GGGCAGAGCTGGGCAGCGGGCTGGAGTTCCCGGGCGCCGAGGGCCAGTGGACGCGCTTCCCCAAGTGGAA
  CGCGTGCTGCGAGAGCGAGATGAGCTTCCAGCTGAAGACGCGCAGTGCCCGCGGCCTCGTGCTCTACTTC
  GACGACGAGGGCTTCTGCGACTTCCTCGAGCTCATCCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
  CCATCTTCTGCGCCGAGCCCGCCACGCTGTTGGCCGACACGCCGGTCAACGACGGCGCCTGGCACAGCGT
  GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTACATCGACCGCGCCGAGGCCAAGTGGGTGGAGGTC
  AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGGCTCTTCGTGGGCGGCCTGCCACCCGAACTGCGCG
  CCGCGGCCCTCAAGCTCACGCTGGCCTCGGTGCGCGAGCGCGAGCCCTTCAAGGGCTGGATCCGTGACGT
  CCGGGTCAACTCGTCACAGGCCCTGCCGGTGGACGGCGGCGAGGTCAAGCTGGACGACGAGCCTCCCAAC
  AGCGGTGGCGGGAGCCCATGCGAGGCGGGCGAAGAAGGCGAGGGCGGCGTGTGCCTCAACGGGGGCGTGT
  GCTCCGTGGTCGACGACCAGGCCGTATGCGACTGCTCGAGGACCGGCTTCCGTGGCAAGGACTGCAGCCA
  AGAAGACAACAATGTGGAAGGTCTGGCACACCTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAA
  GAGTATATTGCCACGTTCAAGGGATCTGAATACTTCTGCTACGACTTATCTCAAAACCCCATTCAAAGCA
  GCAGTGATGAAATAACTCTGTCCTTTAAAACTCTTCAAAGGAACGGACTGATGCTTCACACAGGGAAATC
  AGCTGATTATGTCAATCTTGCATTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCC
  TTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCA
  GGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTGACAATATCAGTGGATGGAATTCTTACCAC
  AACGGGCTACACGCAAGAAGATTACACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGCCCC
  AGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTTGTATATA
  AAAATAATGATGTAAGGCTGGAATTATCGCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATTCACGG
  TGTGGTGGCTTTTAAGTGTGAAAATGTGGCAACCTTAGACCCAATAACTTTTGAGACCCCGGAATCTTTC
  ATTTCTTTGCCTAAGTGGAATGCAAAGAAAACAGGCTCAATATCATTTGATTTCCGTACAACGGAGCCAA
  ATGGCCTCATCCTGTTTAGCCATGGCAAGCCAAGACATCAGAAGGATGCCAAGCACCCACAGATGATTAA
  GGTTGACTTTTTTGCTATTGAGATGCTGGATGGCCACTTGTACCTCCTCTTAGACATGGGATCAGGTACT
  ATAAAAATCAAAGCCCTGCAGAAGAAAGTCAATGATGGAGAATGGTATCACGTGGATTTCCAACGGGATG
  GACGGTCAGGTACCATTTCTGTCAACACACTACGCACTCCCTACACAGCTCCCGGTGAGAGTGAGATCCT
  GGACCTAGATGATGAGTTGTACCTGGGTGGCTTGCCAGAAAATAAGGCTGGCCTAGTCTTCCCTACCGAG
  GTGTGGACTGCTCTGCTCAACTACGGCTACGTGGGCTGCATCCGGGACCTATTTATTGATGGCCAGAGCA
  AAGACATCCGGCAGATGGCGGAAATTCAGAGCACTGCTGGAGTGAAGCCATCCTGCTCAAAAGAGACAGC
  AAAACCGTGCCTTAGCAATCCTTGCAAAAACAATGGCATGTGCAGAGATGGCTGGAACAGATACGTCTGC
  GATTGCTCCGGAACAGGCTATCTCGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTACGACGGGA
  GCATGTTCATGAAAATCCAGCTTCCGGTGGTGATGCACACTGAGGCTGAGGACGTGTCCTTGCGGTTCCG
  ATCCCAGCGTGCATATGGTATCCTGATGGCGACCACTTCTAGAGACTCTGCAGACACCCTTCGATTGGAG
  CTAGATGCAGGACGTGTGAAACTCACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAG
  GTCCTGAGACCCTTTTTGCTGGCTATAACCTCAATGATAATGAATGGCACACAGTGCGTGTGGTTCGGCG
  AGGAAAAAGTTTAAAGCTAACCGTGGATGATCAACAAGCCATGACAGGCCAAATGGCAGGTGATCATACA
  AGGCTGGAGTTTCATAACATAGAGACAGGCATCATCACCGAACGACGCTACCTTTCTTCTGTCCCCTCCA
  ATTTCATTGGGCACCTGCAAAGCCTGACATTTAATGGAATGGCATACATAGACTTGTGCAAAAATGGTGA
  TATAGATTACTGTGAACTCAATGCCAGGTTTGGATTCAGGAACATCATCGCAGATCCTGTCACCTTCAAG
  ACCAAATCGAGCTATGTTGCCTTAGCTACATTGCAAGCCTACACCTCTATGCATCTATTTTTCCAATTCA
  AGACAACATCTCTAGATGGACTAATTCTGTATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATT
  AGTTAAAGGGTACTTACATTATGTGTTTGACTTGGGAAACGGTGCTAACCTCATCAAAGGGAGCTCAAAC
  AAACCACTCAACGACAATCAGTGGCACAATGTGATGATTTCACGGGACACCAGCAATCTCCACACAGTAA
  AGATCGACACAAAAATCACAACACAAATCACTGCGGGAGCCAGAAATCTAGACCTCAAGAGTGACTTGTA
  TATTGGAGGAGTGGCTAAAGAAACATATAAATCCCTGCCAAAACTGGTCCATGCCAAAGAAGGCTTTCAA
  GGTTGCCTGGCATCTGTGGACTTGAATGGCAGACTTCCAGATCTCATCTCGGATGCTCTCTTCTGCAATG
  GGCAAATTGAGAGAGGATGCGAAGGGCCCAGCACAACCTGCCAAGAGGATTCATGTTCAAATCAAGGCGT
  TTGCTTGCAGCAATGGGATGGCTTCAGCTGTGACTGTAGCATGACTTCCTTCAGTGGCCCACTCTGCAAT
  GACCCTGGGACAACATATATCTTTAGCAAAGGTGGTGGACAGATTACATATAAGTGGCCTCCCAATGACC
  GCCCCAGTACACGAGCAGACAGGCTGGCCATCGGATTTAGCACTGTCCAGAAGGAAGCCGTGTTGGTGCG
  TGTGGACAGTTCCTCAGGACTGGGTGACTACCTGGAGCTGCACATACACCAAGGAAAAATTGGAGTTAAG
  TTTAATGTTGGGACAGATGACATCGCCATCGAAGAGTCTAATGCAATCATTAATGATGGGAAATACCATG
  TAGTACGTTTCACAAGGAGTGGTGGCAATGCCACGTTACAGGTGGACAGCTGGCCAGTTATCGAACGCTA
  CCCTGCAGGAAACAATGATAACGAGCGCCTGGCGATTGCTAGACAGCGAATTCCATATCGACTTGGTCGA
  GTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAA
  TTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCCAGCTCTCTGGTCTTTACTACAATGGCTTGAAAGT
  TCTGAATATGGCAGCAGAGAACGATGCCAACATCGCCATAGTGGGGAATGTGAGGCTGGTCGGTGAAGTG
  CCTTCCTCTATGACAACTGAGTCGACAGCCACTGCCATGCAGTCTGAGATGTCCACCTCAATCATGGAGA
  CCACCACAACCCTGGCTACCAGCACAGCTAGAAGAGGCAAGCCCCCCACAAAGGAACCCATCAGCCAGAC
  CACAGATGACATCCTTGTGGCCTCGGCAGAGTGTCCCAGTGACGATGAGGACATTGACCCCTGTGAGCCG
  AGCTCAGGTGGGTTAGCCAACCCCACCAGAGTAGGTGGCCGTGAACCATACCCAGGCTCTGCAGAGGTGA
  TTCGGGAGTCCAGCAGTACCACTGGCATGGTGGTGGGGATTGTCGCAGCAGCCGCTCTGTGCATCCTCAT
  CCTCCTCTATGCCATGTACAAGTACAGGAACCGGGATGAAGGGTCGTACCACGTGGATGAGAGTCGAAAC
  TACATCAGTAACTCAGCACAGTCCAATGGGGCTGTGGTCAAGGAGAAGCAACCCAGCAGTGCTAAAAGCG
  CCAACAAAAACAAGAAAAACAAGGATAAGGAGTATTACGTCTGA
  
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
  TGGATTACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-RsrII
• ACCN: NM_020252
• ORF Size: 4524 bp
• Insert Size: 4524
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_020252.3, NP_064648.3
• RefSeq Size: 9040
• RefSeq ORF: 4524
• Locus ID: 18189
• Gene Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]