Hc (NM_010406) Mouse Untagged Clone

CAT#: MC224814

Hc (untagged) - Mouse hemolytic complement (Hc), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Hc
• Synonyms: C5; C5a; He; Hfib2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC224814 representing NM_010406
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCGCTACCAGCCATGGGTCTTTGGGGAATACTTTGTCTTTTAATTTTCCTGGACAAAACTTGGGGAC
  AGGAACAAACCTACGTCATTTCAGCACCCAAAATCCTCCGGGTCGGCTCGTCTGAAAATGTGGTAATTCA
  AGTCCATGGCTACACTGAAGCATTTGATGCAACTCTTTCTCTAAAAAGCTATCCTGACAAAAAAGTCACC
  TTCTCTTCAGGCTATGTTAATTTGTCCCCGGAAAACAAATTCCAAAACGCGGCACTGTTGACACTACAGC
  CCAATCAAGTTCCTAGAGAAGAAAGCCCAGTCTCTCACGTGTATCTGGAAGTTGTGTCAAAACACTTTTC
  AAAATCAAAGAAAATACCAATTACCTATAACAATGGAATTCTCTTCATCCATACAGACAAACCTGTTTAC
  ACGCCGGACCAGTCAGTAAAGATCAGAGTCTATTCTCTGGGTGACGACTTGAAGCCAGCCAAACGGGAGA
  CTGTCTTAACTTTCATAGACCCCGAAGGATCAGAAGTTGACATTGTAGAAGAAAATGATTACACCGGAAT
  TATCTCTTTTCCTGACTTCAAGATTCCATCTAATCCCAAGTATGGTGTTTGGACAATTAAAGCTAACTAT
  AAGAAGGATTTTACAACAACTGGAACTGCATACTTTGAAATTAAAGAATATGTCTTGCCACGATTCTCTG
  TTTCAATAGAACTAGAAAGAACCTTCATTGGCTATAAAAACTTTAAGAACTTTGAAATCACTGTGAAAGC
  AAGATATTTTTATAATAAAGTGGTACCTGATGCTGAAGTGTATGCCTTTTTTGGATTGAGAGAGGACATA
  AAAGATGAGGAGAAGCAGATGATGCACAAAGCCACACAAGCCGCAAAGTTGGTTGACGGAGTTGCTCAGA
  TCTCTTTTGATTCTGAAACAGCAGTTAAAGAGCTGTCCTACAACAGTCTAGAAGACTTAAACAACAAGTA
  CCTTTATATTGCAGTAACAGTCACAGAATCTTCAGGTGGATTTTCAGAAGAGGCAGAAATCCCTGGAGTC
  AAATATGTCCTCTCTCCCTACACACTGAATTTGGTCGCTACTCCTCTTTTCGTGAAGCCCGGGATTCCAT
  TTTCCATCAAGGCACAGGTTAAAGATTCACTCGAGCAGGCGGTAGGAGGGGTCCCAGTAACTCTGATGGC
  ACAAACAGTCGATGTGAATCAAGAGACATCTGACTTGGAAACAAAGAGGAGCATCACTCATGACACTGAT
  GGAGTAGCTGTGTTTGTGCTGAACCTCCCATCAAATGTGACGGTGCTAAAGTTTGAGATCAGAACTGATG
  ACCCAGAACTTCCCGAAGAAAATCAAGCCAGCAAAGAGTACGAAGCAGTTGCGTACTCGTCTCTCAGCCA
  AAGTTACATTTACATCGCTTGGACTGAAAACTACAAGCCCATGCTTGTGGGAGAATACCTGAATATTATG
  GTTACCCCCAAGAGCCCATATATCGACAAAATAACTCACTATAATTACTTGATTTTATCCAAAGGCAAAA
  TTGTACAGTACGGCACAAGAGAGAAACTTTTCTCCTCAACTTATCAAAATATAAATATTCCAGTGACACA
  GAACATGGTTCCTTCAGCACGACTCCTGGTCTATTACATAGTCACAGGGGAGCAAACAGCAGAATTAGTG
  GCTGACGCAGTCTGGATAAATATTGAGGAGAAGTGTGGCAACCAGCTCCAGGTCCATCTGTCTCCAGATG
  AATATGTGTATTCTCCAGGCCAAACTGTGTCCCTTGACATGGTGACTGAAGCAGACTCATGGGTAGCACT
  ATCAGCAGTGGACAGAGCTGTGTATAAAGTCCAGGGAAACGCCAAAAGGGCCATGCAAAGAGTCTTTCAA
  GCTTTGGATGAAAAGAGTGACCTGGGCTGTGGGGCAGGTGGTGGCCATGACAATGCAGATGTATTCCATC
  TAGCTGGGCTCACCTTCCTCACCAACGCAAACGCAGATGACTCCCATTATCGTGATGACTCTTGTAAAGA
  AATTCTCAGGTCAAAGAGAAACCTGCATCTCCTAAGGCAGAAAATAGAAGAACAAGCTGCTAAGTACAAA
  CATAGTGTGCCAAAGAAATGCTGCTATGACGGAGCCCGAGTGAACTTCTACGAAACCTGTGAGGAGCGAG
  TGGCCCGGGTTACCATAGGCCCTCTCTGCATCAGGGCCTTCAACGAGTGCTGTACTATTGCGAACAAGAT
  CCGAAAAGAAAGCCCCCATAAACCTGTCCAACTGGGAAGGATCCACATTAAGACCCTGTTACCAGTGATG
  AAGGCAGATATCCGAAGCTACTTTCCAGAGAGCTGGCTATGGGAAATTCATCGCGTTCCCAAAAGAAAAC
  AGCTGCAGGTCACGCTGCCTGACTCACTAACGACTTGGGAAATTCAAGGCATTGGCATTTCAGACAATGG
  TATATGTGTTGCTGATACACTCAAGGCAAAGGTGTTCAAAGAAGTCTTCCTGGAGATGAACATACCATAT
  TCTGTTGTGCGAGGAGAACAGATCCAATTGAAAGGAACTGTTTACAACTATATGACCTCAGGGACAAAGT
  TCTGTGTTAAAATGTCTGCTGTGGAGGGGATCTGCACTTCAGGAAGCTCAGCTGCTAGCCTTCACACCTC
  CAGGCCCTCCAGATGTGTGTTCCAGAGGATAGAGGGCTCGTCCAGTCACTTGGTGACCTTCACCCTGCTT
  CCTCTGGAAATTGGCCTTCACTCCATAAACTTCTCACTAGAGACCTCATTTGGGAAAGACATCTTAGTAA
  AGACATTACGGGTAGTGCCAGAAGGAGTCAAGAGGGAAAGCTATGCCGGCGTGATTCTGGACCCTAAGGG
  AATTCGTGGTATTGTTAACAGACGAAAGGAATTCCCATACAGGATCCCATTAGATTTGGTCCCCAAGACC
  AAAGTTGAAAGGATTTTGAGTGTCAAAGGACTGCTTGTAGGGGAGTTCTTGTCCACGGTTCTGAGTAAGG
  AAGGCATCAACATCCTAACCCACCTCCCCAAGGGCAGTGCAGAGGCAGAGCTCATGAGCATAGCTCCGGT
  GTTCTATGTTTTCCACTACCTGGAAGCAGGAAACCATTGGAATATTTTCTATCCTGATACACTGAGTAAA
  AGACAGAGCCTGGAGAAAAAAATAAAACAAGGGGTGGTGAGCGTCATGTCCTACAGAAACGCTGACTATT
  CCTACAGCATGTGGAAGGGGGCGAGCGCTAGTACCTGGCTGACAGCTTTTGCTCTGAGAGTGCTTGGACA
  GGTGGCCAAGTATGTAAAACAGGATGAAAACTCAATTTGTAACTCTTTGCTATGGCTGGTTGAGAAGTGT
  CAGCTGGAAAACGGCTCTTTCAAGGAAAATTCCCAATATCTACCAATAAAATTACAGGGTACTTTGCCTG
  CTGAAGCCCAAGAGAAAACTTTGTATCTTACAGCCTTTTCTGTGATTGGAATTAGAAAGGCAGTTGACAT
  ATGCCCCACCATGAAAATCCACACAGCGCTAGATAAAGCCGACTCCTTCCTGCTTGAAAACACCCTGCCA
  TCCAAGAGCACCTTCACACTGGCCATTGTAGCCTATGCTCTTTCCCTAGGAGACAGAACCCACCCGAGGT
  TTCGTCTAATTGTGTCGGCCCTGAGGAAGGAAGCTTTTGTTAAAGGTGATCCGCCCATTTACCGTTACTG
  GAGAGATACCCTCAAACGTCCAGACAGCTCTGTGCCCAGCAGCGGCACAGCAGGTATGGTTGAAACCACA
  GCCTATGCTTTGCTCGCCAGCCTGAAACTGAAGGATATGAATTACGCCAACCCCATCATCAAGTGGCTAT
  CTGAAGAGCAGAGGTATGGAGGCGGCTTTTATTCCACCCAGGATACGATTAATGCCATCGAGGGCCTGAC
  AGAATATTCACTCCTGTTAAAACAAATTCATTTGGATATGGACATCAATGTCGCCTACAAACACGAAGGT
  GACTTCCACAAGTATAAGGTGACAGAGAAGCATTTCCTGGGGAGGCCAGTGGAGGTATCTCTCAATGATG
  ACCTTGTTGTCAGCACAGGCTACAGCAGTGGCTTGGCCACAGTATATGTAAAAACTGTGGTTCACAAAAT
  TAGTGTCTCTGAGGAATTTTGCAGCTTTTACTTGAAAATTGATACCCAAGATATTGAAGCATCCAGCCAC
  TTCAGGCTCAGTGACTCTGGATTCAAGCGCATAATAGCATGTGCCAGCTACAAGCCCAGCAAGGAGGAGT
  CAACATCCGGGTCCTCCCATGCAGTAATGGATATATCACTGCCGACTGGAATCGGAGCAAACGAGGAAGA
  TTTACGGGCTCTTGTGGAAGGAGTGGATCAACTACTAACTGATTACCAGATCAAAGATGGCCATGTCATT
  CTGCAACTGAATTCGATCCCCTCCAGAGATTTCCTCTGTGTCCGGTTCCGGATATTTGAACTTTTCCAAG
  TTGGGTTTCTGAATCCTGCTACCTTCACGGTGTACGAGTATCACAGACCAGATAAGCAGTGCACCATGAT
  TTATAGCATTTCTGACACCAGGCTTCAGAAAGTCTGTGAAGGAGCAGCTTGCACATGTGTGGAAGCTGAC
  TGTGCGCAACTGCAGGCAGAAGTAGACCTAGCCATCTCTGCAGACTCCAGAAAAGAGAAAGCCTGTAAAC
  CAGAGACTGCATATGCTTATAAAGTCAGGATCACATCAGCCACTGAAGAAAATGTTTTTGTCAAGTACAC
  TGCGACTCTTCTGGTCACTTACAAAACAGGGGAAGCTGCTGATGAGAATTCGGAGGTCACCTTCATTAAA
  AAGATGAGCTGTACCAATGCCAACCTGGTGAAAGGGAAGCAGTATTTAATCATGGGCAAAGAGGTTCTGC
  AGATCAAACACAATTTCAGTTTCAAGTATATATACCCTCTAGATTCCTCCACCTGGATTGAATATTGGCC
  CACAGACACAACGTGTCCATCCTGTCAAGCATTTGTAGAGAATTTGAATAACTTTGCTGAAGACCTCTTT
  TTAAACAGCTGTGAATGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_010406
• ORF Size: 5058 bp
• Insert Size: 5058
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_010406.2, NP_034536.2
• RefSeq Size: 5448
• RefSeq ORF: 5043
• Locus ID: 15139
• Gene Summary: This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]