Stk11 (NM_001301853) Mouse Untagged Clone

CAT#: MC227561

Stk11 (untagged) - Mouse serine/threonine kinase 11 (Stk11), transcript variant 2

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Stk11
• Synonyms: AA408040; Lkb1; Par-4; R75140
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC227561 representing NM_001301853
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGACGTGGCGGACCCCGAGCCGTTGGGCCTTTTCTCCGAGGGCGAGCTGATGTCGGTGGGCATGGACA
  CCTTCATCCACCGCATCGACTCCACCGAGGTAATCTACCAGCCGCGCCGCAAACGCGCCAAGCTCATCGG
  CAAGTACCTGATGGGGGACCTGCTCGGGGAGGGCTCGTACGGCAAGGTGAAGGAGGTGCTGGACTCCGAG
  ACCTTATGCCGCAGGGCGGTCAAGATCCTCAAGAAGAAAAAGCTGCGCAGGATCCCCAATGGAGAGGCCA
  ACGTCAAGAAGGAGATCCAGCTGCTGCGGCGGCTGCGGCATCGGAATGTGATCCAGCTTGTGGACGTGCT
  GTACAATGAGGAGAAGCAGAAGATGTATATGGTGATGGAGTACTGCGTATGTGGCATGCAGGAGATGCTG
  GACAGTGTGCCGGAGAAGCGCTTCCCTGTGTGCCAAGCTCATGGGTACTTCCGCCAGCTGATTGACGGCC
  TGGAATACCTACACAGCCAGGGCATTGTTCACAAGGACATCAAGCCGGGCAACCTGCTACTCACCACCAA
  TGGCACACTCAAGATCTCCGACCTCGGTGTTGCCGAGGCCCTGCACCCTTTCGCTGTGGATGACACCTGC
  CGGACAAGCCAGGGCTCCCCGGCCTTCCAGCCTCCTGAGATTGCCAATGGACTGGACACCTTTTCAGGTT
  TCAAGGTGGACATCTGGTCAGCTGGGGTCACACTTTACAACATCACCACGGGCCTGTACCCATTTGAGGG
  GGACAATATCTACAAGCTCTTTGAGAACATTGGGAGAGGAGACTTCACCATCCCTTGTGACTGCGGCCCA
  CCACTCTCTGACCTACTCCGAGGGATGTTGGAGTATGAGCCGGCCAAGAGGTTCTCCATCCGACAGATTA
  GGCAGCACAGCTGGTTCCGGAAGAAACACCCTCTGGCTGAGGCGCTCGTACCTATCCCACCAAGCCCAGA
  CACTAAGGACCGCTGGCGCAGTATGACTGTAGTGCCCTACCTGGAGGACCTGCATGGCCGTGCGGAGGAG
  GAGGAGGAGGAAGACTTGTTTGACATTGAGGACGGCATTATCTACACCCAGGACTTCACAGTGCCTGGTG
  TCGAGGAGGCGGCCGAGGCAGGGCTTAGCGAGGATGCATGCGACACATGCATGTGGAAGAGCCAGGGCGC
  AGGCCTTCCTGGAGAGGAGCCCGAGGAGGGGTTTGGGGCTTTAGTGTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001301853
• ORF Size: 1239 bp
• Insert Size: 1239
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001301853.1, NP_001288782.1
• RefSeq Size: 2054
• RefSeq ORF: 1239
• Locus ID: 20869
• Gene Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
  Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (S, see PMID:18774945) has a distinct C-terminus and is shorter than isoform L. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.