Syngap1 (NM_001281491) Mouse Untagged Clone

CAT#: MC229566

Syngap1 (untagged) - Mouse synaptic Ras GTPase activating protein 1 homolog (rat) (Syngap1)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Syngap1
• Synonyms: Gm1963; Syngap
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC229566 representing NM_001281491
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAGCAGGTCTCGAGCCTCCATCCATCGGGGGAGCATCCCCGCGATGTCCTATGCCCCCTTCAGAGATG
  TACGGGGACCCCCTATGCACCGAACCCAATACGTTCATTCCCCGTACGATCGTCCTGGCTGGAACCCTCG
  GTTCTGCATCATCTCGGGGAACCAGCTGCTCATGCTGGATGAGGATGAGATACACCCCCTTCTGATCCGC
  GACCGGAGGAGCGAGTCCAGCCGAAACAAACTGCTGAGACGCACCGTCTCTGTGCCAGTGGAGGGGCGGC
  CCCACGGCGAGCATGAATACCACTTGGGTCGCTCGAGGAGGAAGAGTGTCCCAGGGGGGAAACAGTACAG
  CATGGAGGCCGCCCCCGCTGCGCCCTTCCGGCCCTCGCAAGGCTTCCTGAGCCGGAGGCTAAAAAGCTCT
  ATCAAACGTACAAAGTCACAACCCAAACTTGACCGGACCAGCAGCTTTCGACAGATCCTGCCTCGCTTCC
  GAAGTGCTGACCATGACCGGGCCCGGCTGATGCAGAGCTTCAAGGAGTCACATTCCCACGAGTCCCTGCT
  GAGTCCCAGTAGTGCTGCTGAGGCCTTGGAGCTCAACCTGGATGAAGACTCCATTATCAAGCCAGTACAC
  AGCTCCATCCTGGGTCAGGAGTTCTGCTTTGAGGTAACAACATCATCTGGAACAAAATGCTTTGCCTGTC
  GGTCTGCAGCTGAAAGGGACAAATGGATTGAGAATCTGCAGAGGGCTGTAAAACCCAACAAGGACAACAG
  CCGCCGAGTAGATAACGTGCTGAAGCTATGGATCATAGAGGCTCGAGAGCTGCCCCCCAAGAAGAGATAT
  TACTGTGAGCTGTGCCTGGACGACATGCTGTATGCACGAACCACCTCCAAGCCCCGCTCGGCTTCAGGAG
  ACACCGTCTTTTGGGGCGAGCACTTTGAGTTTAACAACCTGCCTGCCGTCCGGGCCCTTCGGCTGCATCT
  GTACCGTGACTCAGACAAAAAGCGGAAGAAGGACAAGGCTGGCTACGTTGGCCTGGTGACTGTTCCAGTG
  GCCACCCTAGCTGGGCGCCACTTCACAGAGCAGTGGTACCCCGTGACCTTGCCGACAGGCAGTGGGGGCT
  CTGGGGGCATGGGCTCGGGGGGAGGAGGAGGGTCAGGGGGTGGCTCAGGGGGCAAAGGGAAAGGAGGTTG
  TCCTGCTGTGAGACTGAAAGCCCGTTACCAGACGATGAGCATCCTGCCCATGGAGCTGTATAAGGAGTTT
  GCAGAGTATGTGACCAACCATTACCGGATGCTATGTGCAGTGCTGGAGCCTGCCCTGAATGTCAAAGGCA
  AGGAAGAGGTGGCCAGTGCACTGGTTCACATCCTGCAGAGCACAGGCAAGGCCAAGGACTTCCTTTCAGA
  CATGGCCATGTCAGAGGTAGACCGATTCATGGAGCGGGAACACCTCATATTCCGAGAGAACACGCTCGCC
  ACTAAAGCCATAGAAGAGTATATGAGACTGATTGGCCAGAAATACCTCAAGGATGCCATTGGGGAGTTCA
  TTCGTGCTCTGTATGAATCTGAGGAGAACTGTGAAGTAGACCCCATCAAGTGCACAGCGTCCAGTCTGGC
  AGAGCACCAGGCCAACCTGCGGATGTGCTGTGAGTTGGCCCTGTGCAAGGTGGTCAACTCCCATTGCGTG
  TTCCCGAGGGAGCTGAAGGAGGTGTTTGCATCTTGGCGGCTGCGCTGCGCAGAGCGGGGCCGAGAGGACA
  TTGCTGACAGGCTGATCAGCGCCTCGCTCTTCCTGCGCTTCCTCTGCCCGGCCATTATGTCGCCCAGTCT
  ATTTGGGCTTATGCAGGAGTACCCAGATGAGCAGACCTCACGAACCCTCACCCTCATCGCCAAGGTCATC
  CAGAACCTGGCCAACTTTTCCAAGTTTACCTCAAAGGAGGACTTCCTGGGCTTCATGAATGAGTTTCTGG
  AGCTGGAGTGGGGCTCTATGCAGCAGTTCTTGTATGAGATATCCAACCTGGACACCTTGACCAACAGCAG
  CAGTTTTGAGGGCTATATAGACTTGGGCCGCGAGCTCTCCACACTTCACGCCCTGCTCTGGGAGGTGCTG
  CCCCAGCTCAGCAAGGAAGCCCTCCTGAAGCTGGGCCCACTGCCCCGGCTCCTCAATGACATCAGCACAG
  CCCTGAGGAACCCTAACATCCAAAGGCAGCCAAGCCGCCAGAGTGAACGGACTCGGTCTCAGCCCATGGT
  GCTGCGAGGGCCATCAGCCGAGATGCAGGGCTACATGATGCGGGACCTCAATAGCTCCATCGACCTTCAA
  TCCTTCATGGCTCGAGGCCTCAACAGCTCTATGGACATGGCTCGCCTCCCCTCCCCAACCAAGGAAAAAC
  CACCACCACCACCACCCGGTGGGGGTAAAGACCTTTTCTATGTGAGCCGGCCACCACTGGCCCGGTCCTC
  CCCAGCATACTGCACGAGCAGCTCGGACATCACAGAGCCAGAGCAGAAGATGCTGAGTGTCAACAAGAGT
  GTGTCCATGCTGGACCTTCAGGGCGACGGGCCTGGAGGTCGCCTTAACAGTAGCAGTGTTTCCAACCTGG
  CAGCTGTTGGGGACTTGTTGCATTCCAGCCAGGCCTCGCTGACAGCAGCTTTGGGGTTGCGGCCTGCACC
  TGCCGGGCGCCTCTCCCAGGGGAGTGGCTCTTCCATCACAGCAGCTGGCATGCGCCTCAGCCAGATGGGG
  GTCACTACAGATGGTGTCCCCGCCCAGCAACTGCGCATCCCCCTTTCCTTCCAGAACCCTCTCTTCCATA
  TGGCTGCTGATGGGCCAGGGCCCCCAGCAGGCCATGGAGGGAGCAGTGGTCATGGTCCACCTTCCTCCCA
  TCACCACCACCACCACCATCACCACCACCGAGGGGGAGAACCCCCAGGGGACACTTTTGCCCCATTCCAT
  GGCTATAGCAAGAGCGAGGACCTCTCTTCAGGGGTCCCTAAGCCCCCCGCCGCCTCCATCCTTCACAGCC
  ACAGCTACAGCGACGAGTTTGGACCCTCTGGCACTGATTTTACCCGCCGGCAGCTCTCGCTTCAGGACAG
  TCTACAGCACATGCTCTCCCCTCCCCAGATTACCATCGGTCCCCAGAGGCCAGCTCCCTCAGGGCCGGGA
  GGGGGCAGCGGCGGGGGCAGCGGTGGGGGCCAGCCACCCCCCTTGCAGAGGGGCAAGTCTCAACAGTTGA
  CAGTGAGTGCCGCCCAGAAACCTCGGCCGTCTAGCGGGAACCTGTTGCAGTCCCCGGAGCCAAGCTACGG
  ACCTGCCCGTCCTCGGCAGCAGAGCCTCAGCAAAGAGGGCAGCATTGGGGGCAGCGGGGGCAGCGGGGGC
  GGAGGGGGTGGGGGGCTCAAGCCCTCCATCACCAAGCAGCATTCCCAGACTCCATCCACGCTTAACCCCA
  CAATGCCAGCCTCGGAGCGGACCGTAGCCTGGGTCTCCAACATGCCTCACCTGTCGGCTGACATCGAGAG
  TGCACACATCGAGCGAGAAGAGTACAAGCTCAAGGAGTACTCCAAGTCCATGGACGAAAGCCGGCTGGAC
  AGGGTGAAGGAGTATGAGGAGGAGATACATTCGCTGAAGGAGAGGCTACACATGTCCAACCGGAAGCTGG
  AAGAGTATGAGCGGAGGTTGCTGTCCCAGGAAGAACAGACCAGCAAGATCCTGATGCAGTACCAAGCCCG
  CCTGGAGCAGAGTGAGAAGCGCTTGAGACAGCAGCAGGTGGAGAAGGACTCCCAGATCAAGAGCATCATT
  GGCAGGCTGATGCTGGTGGAGGAGGAGCTGCGTCGGGACCACCCCGCCATGGCTGAGCCGCTGCCTGAGC
  CCAAGAAGAGGCTGCTCGACGCTCAGGAGAGGCAGCTTCCCCCCTTGGGTCCAACAAACCCGCGTGTGAC
  GCTGGCCCCACCTTGGAACGGCCTGGCCCCCCCAGCCCCACCCCCCCCACCCCGGCTGCAGATCACAGAG
  AACGGCGAGTTCCGGAACACCGCAGACCACTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001281491
• ORF Size: 4023 bp
• Insert Size: 4023
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001281491.1, NP_001268420.1
• RefSeq Size: 4023
• RefSeq ORF: 4023
• Locus ID: 240057
• Gene Summary: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]