Igfbp3 (NM_008343) Mouse Tagged ORF Clone

CAT#: MR204018

Igfbp3 (Myc-DDK-tagged) - Mouse insulin-like growth factor binding protein 3 (Igfbp3)

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Igfbp3
• Synonyms: AI649005; IGFBP-3; IGgfbp3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR204018 representing NM_008343
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCATCCCGCGCGCCCCGCGCTCTGGGCGGCTGCGCTCACTGCCCTCACTCTGCTCCGCGG[AT]CCGC
  CGGTGGCGCGAGCTGGCGCGGGCGCGGTGGGCGCGGGCCCCGTGGTGCGCTGCGAACCGTGCGACGCGCG
  TGCGCTGTCCCAGTGCGCGCCTCCGCCCACTGCGCCCGCGTGCACGGAGCTGGTGCGAGAGCCCGGCTGC
  GGCTGCTGCCTGACTTGCGCGCTGCGCGAAGGCGACGCGTGCGGCGTCTACACGGAGCGCTGTGGCACCG
  GCCTCCGCTGCCAGCCGCGGCCCGCGGAGCAGTACCCGCTGAGGGCGCTGCTGAATGGCCGCGGGTTCTG
  CGCCAACGCCAGCGCTGCAGGCAGCCTAAGCACCTACCTCCCCTCCCAACCTGCTCCAGGAAACATCAGT
  GAGTCCGAGGAGGAGCACAATGCTGGGAGTGTGGAAAGCCAGGTTGTCCCCAGCACACACCGAGTGACCG
  ATTCCAAGTTCCATCCACTCCATGCCAAGATGGATGTCATCAAAAAAGGCCACGCCAGGGACAGCCAGCG
  CTACAAAGTTGACTATGAGTCTCAAAGCACAGACACCCAGAACTTCTCCTCCGAGTCTAAGCGGGAGACA
  GAATACGGTCCCTGCCGCAGAGAAATGGAGGACACACTGAATCATCTGAAGTTCCTCAATGTGCTGAGTC
  CCAGAGGCGTCCACATCCCAAACTGTGACAAGAAGGGGTTCTATAAGAAGAAGCAGTGCCGCCCTTCCAA
  AGGCAGAAAGCGGGGCTTCTGCTGGTGTGTGGACAAGTATGGGCAGCCCTTGCCAGGCTACGACACCAAG
  GGGAAAGACGACGTACATTGCCTCAGCGTGCAGAGCCAG
  
  ACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGA
  TTACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >MR204018 representing NM_008343
  Red=Cloning site Green=Tags(s)
  
  MHPARPALWAAALTALTLLRXXPPVARAGAGAVGAGPVVRCEPCDARALSQCAPPPTAPACTELVREPGC
  GCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLRALLNGRGFCANASAAGSLSTYLPSQPAPGNIS
  ESEEEHNAGSVESQVVPSTHRVTDSKFHPLHAKMDVIKKGHARDSQRYKVDYESQSTDTQNFSSESKRET
  EYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTK
  GKDDVHCLSVQSQ
  
  TRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-NotI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_008343
• ORF Size: 879 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_008343.2, NP_032369.2
• RefSeq Size: 2456
• RefSeq ORF: 879
• Locus ID: 16009
• MW: 32.1 kDa
• Gene Summary: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. [UniProtKB/Swiss-Prot Function]