Kpna2 (BC003274) Mouse Tagged ORF Clone

CAT#: MR208477

  • TrueORF®

Kpna2 (Myc-DDK-tagged) - Mouse karyopherin (importin) alpha 2 (cDNA clone MGC:6031 IMAGE:3499880)


  "BC003274" in other vectors (3)


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Reconstitution Protocol

USD 560.00

2 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Mouse Tagged ORF Clone
Tag Myc-DDK
Symbol Kpna2
Synonyms IPOA1
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MR208477 representing BC003274
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGTCCACGAACGAGAATGCTAACTTACCAGCTGCCCGACTTAACAGGTTCAAGAACAAGGGGAAGGACA
GCACAGAAATGCGTCGCCGCCGAATAGAAGTTAATGTGGAACTCAGGAAAGCTAAAAAAGATGAGCAGAT
GCTGAAAAGAAGAAACGTCAGCTCCTTTCCTGATGATGCTACTTCTCCGCTACAGGAAAACCGGAACAAC
CAGGGTACTGTAAATTGGTCTGTTGAGGACATTGTTAAAGGCATAAACAGTAACAATTTGGAAAGCCAGC
TCCAAGCTACTCAAGCTGCTCGGAAATTGCTTTCTAGAGAGAAACAGCCTCCTATAGACAACATCATCCG
GGCTGGTTTGATCCCAAAATTTGTGTCCTTCTTGGGCAAAACTGATTGTAGTCCTATTCAGTTTGAGTCT
GCTTGGGCACTCACCAACATTGCTTCTGGAACATCTGAACAGACCAAAGCTGTGGTGGATGGAGGTGCTA
TCCCAGCGTTTATTTCTCTCTTGGCATCTCCTCATGCTCACATCAGCGAGCAAGCTGTTTGGGCTCTTGG
AAACATTGCAGGTGATGGTTCAGCTTTCCGAGACTTAGTTATCAAACACGGTGCGATTGACCCACTGTTG
GCACTTCTTGCAGTTCCCGATCTGTCTACCTTGGCATGTGGTTACTTACGTAATCTTACCTGGACGCTTT
CAAACCTTTGTCGAAACAAGAACCCTGCACCTCCCTTAGATGCCGTTGAGCAGATTCTTCCTACGTTAGT
TCGACTCCTGCACCACAATGATCCAGAAGTATTGGCAGATTCCTGCTGGGCCATTTCCTACCTGACTGAT
GGTCCAAATGAGCGCATTGAGATGGTTGTGAAGAAAGGAGTTGTTCCCCAACTTGTGAAGCTTCTAGGAG
CTACTGAACTGCCCATTGTGACTCCCGCACTAAGAGCCATAGGGAATATTGTCACTGGAACAGATGAGCA
GACTCAGAAAGTGATCGATGCAGGAGCACTTGCAGTCTTTCCCAGCCTGCTAACAAACCCCAAAACTAAT
ATTCAGAAGGAGGCCACATGGACAATGTCGAACATTACAGCTGGACGCCAGGACCAGATACAGCAAGTTG
TGAATCACGGCCTAGTCCCCTTTCTTGTTGGTGTCCTCTCTAAGGCGGACTTTAAGACACAGAAGGAGGC
CGCGTGGGCTATAACCAACTATACCAGCGGTGGGACTGTTGAGCAGATTGTGTATCTCGTTCACTGTGGG
ATAATAGAACCTTTGATGAACCTCCTGAGTGCAAAAGATACCAAGATTATTCAGGTTATTCTTGACGCCA
TTTCAAATATCTTTCAGGCTGCAGAGAAACTAGGTGAGACAGAAAAGCTTAGTATAATGATTGAAGAGTG
TGGAGGCTTGGATAAAATTGAAGCACTACAGAGGCATGAAAACGAGTCTGTATACAAGGCCTCATTGAAC
TTAATTGAGAAGTACTTCTCAGTGGAGGAAGAGGAAGATCAAAATGTGGTGCCAGAAACTACCTCTGAAG
GCTTCGCCTTCCAAGTTCAGGATGGAGCTCCTGGGACCTTTAACTTC


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAG
GTTTAA
>MR208477 representing BC003274
Red=Cloning site Green=Tags(s)

MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNN
QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFES
AWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLL
ALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTD
GPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTN
IQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLN
LIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN BC003274
ORF Size 1587 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC003274.1
RefSeq Size 1962
RefSeq ORF 1589
Locus ID 16647
MW 71.9 kDa
Gene Summary Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [UniProtKB/Swiss-Prot Function]

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