Cntnap1 (NM_016782) Mouse Tagged ORF Clone

CAT#: MR223061

Cntnap1 (Myc-DDK-tagged) - Mouse contactin associated protein-like 1 (Cntnap1)

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Cntnap1
• Synonyms: AI841080; Caspr; NCP1; Nrxn4; p190; shm
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR223061 representing NM_016782
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGATGAGTCTCCGGCTCTTCAGCATCCTGCTCGCCACGGTGGTCTCTGGAGCTTGGGGCTGGGGCTACT
  ACGGTTGCAATGAGGAGCTGGTGGGGCCTCTGTATGCACGGTCTCTGGGCGCTTCTTCCTACTATGGACT
  CTTTACCACAGCCCGCTTTGCCCGGCTACATGGCATCAGTGGATGGTCGCCCCGGATTGGGGACCCGAAT
  CCCTGGCTGCAGATCGACTTAATGAAGAAGCATCGGATCCGGGCTGTGGCCACACAGGGAGCTTTTAATT
  CTTGGGATTGGGTCACACGTTACATGCTGCTCTACGGGGACCGTGTGGACAGCTGGACACCATTCTACCA
  AAAAGGGCACAATGCGACCTTCTTCGGGAATGTCAATGACTCGGCAGTGGTCCGCCATGACCTTCACTAC
  CACTTTACGGCTCGCTACATCCGCATCGTGCCACTGGCCTGGAACCCACGCGGCAAGATTGGCCTGAGGC
  TGGGCATCTATGGTTGTCCCTACACATCCAGCATCCTGTATTTTGACGGCGACGATGCCATCTCATACCG
  CTTCCAGCGAGGCGCCAGCCAAAGTCTTTGGGACGTGTTCGCTTTTAGTTTCAAGACAGAGGAGAAGGAT
  GGGCTGTTGCTGCACACCGAGGGCTCCCAGGGGGATTATGTGACGCTTGAACTGCAAGGGGCGCACCTGC
  TGCTGCACATGAGCCTGGGCAGCAGTCCCATCCAGCCAAGACCTGGTCACACCACGGTGAGCCTTGGTGG
  CGTTCTTAACGACCTAAGCTGGCACTATGTGCGGGTGGATCGATATGGCCGAGATGCAAATTTCACCCTG
  GATGGTTACGCCCATCACTTTGTGCTCAACGGCGACTTTGAAAGGCTGAATCTTGAAAATGAGATATTCA
  TCGGGGGTCTAGTGGGCGCAGCCCGTAAGAACCTGGCCTACCGCCATAACTTCCGTGGCTGCATAGAAAA
  CGTGATCTACAACCGGATCAACATTGCAGAAATGGCAGTGATGCGCCATTCGCGGATCACCTTTGAGGGT
  AATGTGGCTTTCCGTTGCTTGGATCCCGTTCCACACCCCATCAACTTCGGAGGCCCTCACAACTTCGTCC
  AAGTGCCTGGCTTTCCACGCCGAGGACGCTTAGCCGTCTCTTTTCGTTTCCGCACCTGGGACCTCACAGG
  GCTGCTCCTTTTCTCCCACTTGGGGGACGGGCTGGGTCATGTGGAGCTGATGCTTAGCGAAGGGCAAGTG
  AATGTATCCATCGCGCAGACTGGCCGCAAGAAGCTTCAGTTTGCTGCTGGGTACCGCCTGAATGATGGCT
  TCTGGCACGAGGTGAACTTTGTGGCACAGGAAAACCATGCAGTCATCAGTATTGATGATGTGGAAGGGGC
  AGAGGTCAGGGTTTCATACCCACTGCTGATCCGCACAGGGACTTCATACTTCTTTGGTGGTTGTCCCAAA
  CCAGCCAGTCGATGGGGCTGCCACTCCAACCAGACAGCATTCCATGGCTGCATGGAGCTGCTCAAGGTGG
  ACGGTCAACTGGTCAACCTCACTCTGGTAGAGTTTCGGAAGCTCGGTTATTTTGCTGAGGTCCTCTTTGA
  CACATGTGGCATCACAGACAGATGCAGCCCTAACATGTGTGAGCATGACGGACGATGCTACCAGTCTTGG
  GATGACTTCATCTGCTACTGCGAACTTACCGGCTACAAGGGAGTTACCTGCCACGAACCATTGTACAAGG
  AGTCCTGTGAGGCCTATCGGCTCAGTGGGAAATATTCTGGAAACTACACCATTGATCCTGATGGCAGTGG
  ACCCCTGAAGCCGTTTGTGGTGTATTGTGACATCCGAGAGAACCGAGCGTGGACAGTTGTGCGGCATGAC
  AGGCTGTGGACCACTCGAGTGACTGGTTCCAGCATGGACCGGCCCTTTCTGGGGGCCATCCAATACTGGA
  ATGCCTCCTGGGAGGAAGTCAGCGCTCTGGCCAATGCTTCCCAACACTGTGAGCAGTGGATCGAGTTTTC
  CTGCTACAATTCCCGGCTGCTCAACACTGCAGGAGGCTACCCCTACAGCTTTTGGATTGGCCGCAATGAG
  GAACAGCATTTCTACTGGGGAGGCTCCCAGCCTGGGATCCAGCGCTGTGCCTGTGGGCTGGACCAGAGCT
  GTGTGGACCCTGCACTGCACTGCAATTGTGATGCCGACCAGCCACAGTGGAGAACAGACAAGGGGCTCCT
  GACCTTTGTAGACCATCTGCCTGTCACTCAGGTAGTGGTAGGTGATACAAACCGCTCAAATTCTGAAGCT
  CAGTTCTTCCTGAGGCCTCTGCGCTGCTATGGTGACCGCAATTCCTGGAACACCATCTCCTTCCACACTG
  GAGCTGCACTGCGTTTCCCTCCGATCCGAGCCAACCACAGCCTCGATGTCTCATTCTACTTCAGGACCTC
  GGCTCCCTCGGGTGTCTTCCTAGAGAACATGGGGGGTCCTTTCTGCCGGTGGCGCCGACCTTACGTGAGA
  GTGGAGCTCAACACATCCCGGGATGTGGTCTTTGCCTTTGATATTGGCAATGGGGATGAGAACCTGACAG
  TGCACTCGGATGACTTTGAGTTTAACGATGATGAGTGGCATTTGGTCCGAGCTGAAATCAACGTGAAGCA
  GGCCCGGCTGCGAGTGGATCACCGGCCCTGGGTGCTAAGGCCCATGCCCCTGCAGACCTACATCTGGCTG
  GTGTATGACCAACCCCTCTATGTGGGATCTGCAGAGCTTAAGAGGCGCCCTTTTGTGGGCTGCTTGAGGG
  CCATGCGTTTGAATGGAGTGACTCTGAACTTGGAGGGCCGTGCCAATGCCTCTGAGGGCACCTTCCCCAA
  CTGCACCGGCCACTGCACCCACCCCCGGTTCCCCTGTTTCCACGGAGGACGCTGTGTGGAGCGATACAGC
  TACTACACATGTGACTGTGACCTCACAGCTTTTGATGGGCCATACTGCAATCACGATATTGGTGGATTCT
  TTGAGACCGGCACATGGATGCGCTATAACCTCCAGTCAGCACTGCGCTCTGCAGCCCGGGAGTTCTCACA
  CATGCTGAGCCGGCCAGTGCCGGGCTATGAGCCTGGCTATGTTCCAGGCTACGACACTCCTGGTTACGTG
  CCTGGATACCACGGCCCTGGGTACCGACTGCCCGAGTACCCGAGGCCCGGCCGGCCAGTGCCCGGGTATA
  GGGGGCCTGTCTACAATGTTACTGGAGAGGAGGTCTCCTTCAGCTTCAGCACCAACTCTGCTCCTGCCGT
  CCTGCTCTATGTCAGCTCCTTTGTACGTGACTACATGGCTGTGCTCATCAAGGAAGACGGGACCCTACAG
  CTTCGGTATCAGTTGGGCACCAGTCCCTATGTGTACCAGCTAACCACCCGGCCAGTGACTGATGGTCAGC
  CCCATAGTGTCAACATCACCCGGGTCTACCGAAACCTCTTTATCCAGGTGGACTACTTCCCGCTGACAGA
  ACAGAAGTTCTCTCTCCTGGTGGACAGCCAGCTGGACTCACCCAAGGCCTTGTATCTAGGGCGTGTGATG
  GAGACAGGAGTCATTGACCCAGAGATTCAGCGGTACAACACCCCAGGTTTCTCAGGCTGCCTGTCTGGTG
  TCCGGTTCAACAATGTGGCTCCTCTCAAGACCCATTTCCGAACCCCTCGGCCCATGACTGCTGAGCTGGC
  GGAGGCCATGCGGGTTCAAGGAGAACTGTCAGAATCTAACTGTGGAGCTATGCCACGCCTTGTCTCTGAG
  GTGCCACCAGAACTTGATCCCTGGTACCTGCCTCCAGATTTCCCATACTACCATGACGACGGATGGATTG
  CCATACTCTTAGGTTTTTTGGTGGCCTTCCTGCTGCTGGGGCTTGTGGGAATGCTGGTGCTGTTCTATCT
  GCAAAATCATCGATACAAGGGCTCCTACCACACCAACGAGCCCAAGGCCACCCACGATTCCCATCCTGGC
  GGCAAAGCTCCCCTCCCTCCCTCAGGCCCTGCCCAGGCCCCTGCCCCTACTCCAGCTCCCACACAGCTTC
  CAACCCCAGCCCCAGCCCCAGCCCCAGCCCCAGCCTCTGGCCCAGGCCCCAGAGACCAGAACCTCCCCCA
  GATCTTGGAGGAGTCCAGGTCTGAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >MR223061 representing NM_016782
  Red=Cloning site Green=Tags(s)
  
  MMSLRLFSILLATVVSGAWGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGISGWSPRIGDPN
  PWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHY
  HFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSSILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKD
  GLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTL
  DGYAHHFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVMRHSRITFEG
  NVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQV
  NVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK
  PASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSW
  DDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYTIDPDGSGPLKPFVVYCDIRENRAWTVVRHD
  RLWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNE
  EQHFYWGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRSNSEA
  QFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCRWRRPYVR
  VELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWL
  VYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYS
  YYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYVPGYDTPGYV
  PGYHGPGYRLPEYPRPGRPVPGYRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVRDYMAVLIKEDGTLQ
  LRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVM
  ETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSE
  VPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPG
  GKAPLPPSGPAQAPAPTPAPTQLPTPAPAPAPAPASGPGPRDQNLPQILEESRSE
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_016782
• ORF Size: 4155 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_016782.2, NP_058062.2
• RefSeq Size: 5360
• RefSeq ORF: 4158
• Locus ID: 53321
• MW: 156.8 kDa
• Gene Summary: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Mice that lack CNTAP1 exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity. [UniProtKB/Swiss-Prot Function]