Mc4r (NM_016977) Mouse Tagged ORF Clone

CAT#: MR225777

Mc4r (Myc-DDK-tagged) - Mouse melanocortin 4 receptor (Mc4r)

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Mc4r
• Synonyms: Mc4-r; Pkcp
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >MR225777 ORF sequence
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAACTCCACCCACCACCATGGCATGTATACTTCCCTCCACCTCTGGAACCGCAGCAGCTACGGGCTGC
  ACGGCAATGCCAGCGAGTCGCTGGGGAAGGGCCACCCGGACGGAGGATGCTATGAGCAACTTTTTGTTTC
  CCCCGAGGTGTTTGTGACTCTGGGTGTCATAAGCCTGTTGGAGAACATTCTAGTGATCGTGGCGATAGCC
  AAGAACAAGAACCTGCACTCACCCATGTACTTTTTCATCTGTAGCCTGGCTGTGGCAGATATGCTGGTGA
  GCGTTTCGAATGGGTCGGAAACCATCGTCATTACCCTGTTAAACAGTACGGATACGGATGCCCAGAGCTT
  CACCGTGAACATTGATAATGTCATTGACTCTGTGATCTGTAGCTCCTTGCTCGCATCCATTTGCAGCCTG
  CTTTCCATTGCGGTGGACAGGTATTTCACTATCTTTTACGCGCTCCAGTACCATAACATCATGACGGTTA
  GGCGGGTCGGGATCATCATAAGTTGTATCTGGGCAGCTTGCACTGTGTCAGGCGTCCTCTTCATCATTTA
  CTCGGACAGCAGCGCTGTCATCATCTGCCTCATTTCCATGTTCTTCACTATGCTAGTTCTCATGGCCTCT
  CTCTATGTCCACATGTTCCTGATGGCGAGGCTTCACATTAAGAGGATTGCTGTCCTCCCAGGCACAGGGA
  CCATCCGCCAGGGTACCAACATGAAGGGGGCGATTACCTTGACCATCCTGATTGGAGTCTTTGTTGTCTG
  CTGGGCCCCGTTCTTTCTCCATTTACTGTTCTACATCTCTTGCCCTCAGAATCCATACTGCGTGTGCTTC
  ATGTCTCATTTTAATTTGTATCTCATACTGATCATGTGTAACGCCGTCATCGACCCTCTCATTTATGCCC
  TCCGGAGTCAAGAACTGAGGAAAACTTTCAAAGAGATCATCTGTTTCTATCCTCTGGGAGGCATCTGTGA
  GTTGTCTAGCAGGTAT
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >MR225777 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIA
  KNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSL
  LSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMAS
  LYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCF
  MSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_016977
• ORF Size: 999 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_016977.1, NM_016977.2, NM_016977.3, NM_016977.4, NP_058673.2
• RefSeq Size: 2783
• RefSeq ORF: 999
• Locus ID: 17202
• MW: 37 kDa
• Gene Summary: This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]