Nrxn1 (NM_177284) Mouse Tagged ORF Clone

CAT#: MR226544L3

  • LentiORF®

Lenti ORF clone of Nrxn1 (Myc-DDK-tagged) - Mouse neurexin I (Nrxn1), transcript variant 2


  "NM_177284" in other vectors (4)


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Reconstitution Protocol

USD 1,770.00

6 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Mouse Tagged ORF Clone
Tag Myc-DDK
Symbol Nrxn1
Synonyms 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
Vector pLenti-C-Myc-DDK-P2A-Puro
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection Puromycin
Sequence Data
The ORF insert of this clone is exactly the same as(MR226544).
Restriction Sites SgfI-RsrII      Cloning Scheme for this gene     
ACCN NM_177284
ORF Size 4485 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_177284.2, NP_796258.2
RefSeq Size 9004
RefSeq ORF 4488
Locus ID 18189
Gene Summary This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]

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