Nrxn1 (NM_177284) Mouse Untagged Clone

CAT#: MC224600

Nrxn1 (untagged) - Mouse neurexin I (Nrxn1), transcript variant 2, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Nrxn1
• Synonyms: 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC224600 representing NM_177284
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGACGGCGCTGGTCCAGCGCGGGGGCTGCTGTCTCCTCTGCCTGTCGCTGCTGCTGCTGGGCTGCT
  GGGCAGAGCTGGGCAGCGGGCTGGAGTTCCCGGGCGCCGAGGGCCAGTGGACGCGCTTCCCCAAGTGGAA
  CGCGTGCTGCGAGAGCGAGATGAGCTTCCAGCTGAAGACGCGCAGTGCCCGCGGCCTCGTGCTCTACTTC
  GACGACGAGGGCTTCTGCGACTTCCTCGAGCTCATCCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
  CCATCTTCTGCGCCGAGCCCGCCACGCTGTTGGCCGACACGCCGGTCAACGACGGCGCCTGGCACAGCGT
  GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTACATCGACCGCGCCGAGGCCAAGTGGGTGGAGGTC
  AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGGCTCTTCGTGGGCGGCCTGCCACCCGAACTGCGCG
  CCGCGGCCCTCAAGCTCACGCTGGCCTCGGTGCGCGAGCGCGAGCCCTTCAAGGGCTGGATCCGTGACGT
  CCGGGTCAACTCGTCACAGGCCCTGCCGGTGGACGGCGGCGAGGTCAAGCTGGACGACGAGCCTCCCAAC
  AGCGGTGGCGGGAGCCCATGCGAGGCGGGCGAAGAAGGCGAGGGCGGCGTGTGCCTCAACGGGGGCGTGT
  GCTCCGTGGTCGACGACCAGGCCGTATGCGACTGCTCGAGGACCGGCTTCCGTGGCAAGGACTGCAGCCA
  AGAAGACAACAATGTGGAAGGTCTGGCACACCTGATGATGGGCGACCAAGGAAAAGAAGAGTATATTGCC
  ACGTTCAAGGGATCTGAATACTTCTGCTACGACTTATCTCAAAACCCCATTCAAAGCAGCAGTGATGAAA
  TAACTCTGTCCTTTAAAACTCTTCAAAGGAACGGACTGATGCTTCACACAGGGAAATCAGCTGATTATGT
  CAATCTTGCATTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCCTTTGAAGCACTA
  GTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCAGGAATCTGCGTC
  AGGTGACAATATCAGTGGATGGAATTCTTACCACAACGGGCTACACGCAAGAAGATTACACCATGCTGGG
  GTCTGATGACTTTTTCTATGTTGGAGGCAGCCCCAGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAAC
  AACTTTATGGGCTGTCTCAAAGAGGTTGTATATAAAAATAATGATGTAAGGCTGGAATTATCGCGACTTG
  CCAAGCAAGGAGATCCTAAGATGAAGATTCACGGTGTGGTGGCTTTTAAGTGTGAAAATGTGGCAACCTT
  AGACCCAATAACTTTTGAGACCCCGGAATCTTTCATTTCTTTGCCTAAGTGGAATGCAAAGAAAACAGGC
  TCAATATCATTTGATTTCCGTACAACGGAGCCAAATGGCCTCATCCTGTTTAGCCATGGCAAGCCAAGAC
  ATCAGAAGGATGCCAAGCACCCACAGATGATTAAGGTTGACTTTTTTGCTATTGAGATGCTGGATGGCCA
  CTTGTACCTCCTCTTAGACATGGGATCAGGTACTATAAAAATCAAAGCCCTGCAGAAGAAAGTCAATGAT
  GGAGAATGGTATCACGTGGATTTCCAACGGGATGGACGGTCAGGTACCATTTCTGTCAACACACTACGCA
  CTCCCTACACAGCTCCCGGTGAGAGTGAGATCCTGGACCTAGATGATGAGTTGTACCTGGGTGGCTTGCC
  AGAAAATAAGGCTGGCCTAGTCTTCCCTACCGAGGTGTGGACTGCTCTGCTCAACTACGGCTACGTGGGC
  TGCATCCGGGACCTATTTATTGATGGCCAGAGCAAAGACATCCGGCAGATGGCGGAAATTCAGAGCACTG
  CTGGAGTGAAGCCATCCTGCTCAAAAGAGACAGCAAAACCGTGCCTTAGCAATCCTTGCAAAAACAATGG
  CATGTGCAGAGATGGCTGGAACAGATACGTCTGCGATTGCTCCGGAACAGGCTATCTCGGCAGGTCCTGT
  GAGAGAGAGGCAACGGTTTTGAGCTACGACGGGAGCATGTTCATGAAAATCCAGCTTCCGGTGGTGATGC
  ACACTGAGGCTGAGGACGTGTCCTTGCGGTTCCGATCCCAGCGTGCATATGGTATCCTGATGGCGACCAC
  TTCTAGAGACTCTGCAGACACCCTTCGATTGGAGCTAGATGCAGGACGTGTGAAACTCACGGTCAATCTA
  GATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCTGAGACCCTTTTTGCTGGCTATAACCTCAATG
  ATAATGAATGGCACACAGTGCGTGTGGTTCGGCGAGGAAAAAGTTTAAAGCTAACCGTGGATGATCAACA
  AGCCATGACAGGCCAAATGGCAGGTGATCATACAAGGCTGGAGTTTCATAACATAGAGACAGGCATCATC
  ACCGAACGACGCTACCTTTCTTCTGTCCCCTCCAATTTCATTGGGCACCTGCAAAGCCTGACATTTAATG
  GAATGGCATACATAGACTTGTGCAAAAATGGTGATATAGATTACTGTGAACTCAATGCCAGGTTTGGATT
  CAGGAACATCATCGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGCCTTAGCTACATTGCAA
  GCCTACACCTCTATGCATCTATTTTTCCAATTCAAGACAACATCTCTAGATGGACTAATTCTGTATAACA
  GTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGGTACTTACATTATGTGTTTGACTTGGG
  AAACGGTGCTAACCTCATCAAAGGGAGCTCAAACAAACCACTCAACGACAATCAGTGGCACAATGTGATG
  ATTTCACGGGACACCAGCAATCTCCACACAGTAAAGATCGACACAAAAATCACAACACAAATCACTGCGG
  GAGCCAGAAATCTAGACCTCAAGAGTGACTTGTATATTGGAGGAGTGGCTAAAGAAACATATAAATCCCT
  GCCAAAACTGGTCCATGCCAAAGAAGGCTTTCAAGGTTGCCTGGCATCTGTGGACTTGAATGGCAGACTT
  CCAGATCTCATCTCGGATGCTCTCTTCTGCAATGGGCAAATTGAGAGAGGATGCGAAGGGCCCAGCACAA
  CCTGCCAAGAGGATTCATGTTCAAATCAAGGCGTTTGCTTGCAGCAATGGGATGGCTTCAGCTGTGACTG
  TAGCATGACTTCCTTCAGTGGCCCACTCTGCAATGACCCTGGGACAACATATATCTTTAGCAAAGGTGGT
  GGACAGATTACATATAAGTGGCCTCCCAATGACCGCCCCAGTACACGAGCAGACAGGCTGGCCATCGGAT
  TTAGCACTGTCCAGAAGGAAGCCGTGTTGGTGCGTGTGGACAGTTCCTCAGGACTGGGTGACTACCTGGA
  GCTGCACATACACCAAGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATCGAAGAG
  TCTAATGCAATCATTAATGATGGGAAATACCATGTAGTACGTTTCACAAGGAGTGGTGGCAATGCCACGT
  TACAGGTGGACAGCTGGCCAGTTATCGAACGCTACCCTGCAGGAAACAATGATAACGAGCGCCTGGCGAT
  TGCTAGACAGCGAATTCCATATCGACTTGGTCGAGTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAG
  CTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCC
  AGCTCTCTGGTCTTTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCAGAGAACGATGCCAACATCGC
  CATAGTGGGGAATGTGAGGCTGGTCGGTGAAGTGCCTTCCTCTATGACAACTGAGTCGACAGCCACTGCC
  ATGCAGTCTGAGATGTCCACCTCAATCATGGAGACCACCACAACCCTGGCTACCAGCACAGCTAGAAGAG
  GCAAGCCCCCCACAAAGGAACCCATCAGCCAGACCACAGATGACATCCTTGTGGCCTCGGCAGAGTGTCC
  CAGTGACGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAACCCCACCAGAGTAGGT
  GGCCGTGAACCATACCCAGGCTCTGCAGAGGTGATTCGGGAGTCCAGCAGTACCACTGGCATGGTGGTGG
  GGATTGTCGCAGCAGCCGCTCTGTGCATCCTCATCCTCCTCTATGCCATGTACAAGTACAGGAACCGGGA
  TGAAGGGTCGTACCACGTGGATGAGAGTCGAAACTACATCAGTAACTCAGCACAGTCCAATGGGGCTGTG
  GTCAAGGAGAAGCAACCCAGCAGTGCTAAAAGCGCCAACAAAAACAAGAAAAACAAGGATAAGGAGTATT
  ACGTCTGA
  
  AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
  TGGATTACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-RsrII
• ACCN: NM_177284
• ORF Size: 4488 bp
• Insert Size: 4488
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_177284.2, NP_796258.2
• RefSeq Size: 9004
• RefSeq ORF: 4488
• Locus ID: 18189
• Gene Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]