Nrxn1 (NM_177284) Mouse Untagged Clone

CAT#: MC224600

Nrxn1 (untagged) - Mouse neurexin I (Nrxn1), transcript variant 2, (10ug)


  "NM_177284" in other vectors (4)

Reconstitution Protocol

USD 2,020.00

7 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Symbol Nrxn1
Synonyms 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC224600 representing NM_177284
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGGGACGGCGCTGGTCCAGCGCGGGGGCTGCTGTCTCCTCTGCCTGTCGCTGCTGCTGCTGGGCTGCT
GGGCAGAGCTGGGCAGCGGGCTGGAGTTCCCGGGCGCCGAGGGCCAGTGGACGCGCTTCCCCAAGTGGAA
CGCGTGCTGCGAGAGCGAGATGAGCTTCCAGCTGAAGACGCGCAGTGCCCGCGGCCTCGTGCTCTACTTC
GACGACGAGGGCTTCTGCGACTTCCTCGAGCTCATCCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCT
CCATCTTCTGCGCCGAGCCCGCCACGCTGTTGGCCGACACGCCGGTCAACGACGGCGCCTGGCACAGCGT
GCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTACATCGACCGCGCCGAGGCCAAGTGGGTGGAGGTC
AAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGGCTCTTCGTGGGCGGCCTGCCACCCGAACTGCGCG
CCGCGGCCCTCAAGCTCACGCTGGCCTCGGTGCGCGAGCGCGAGCCCTTCAAGGGCTGGATCCGTGACGT
CCGGGTCAACTCGTCACAGGCCCTGCCGGTGGACGGCGGCGAGGTCAAGCTGGACGACGAGCCTCCCAAC
AGCGGTGGCGGGAGCCCATGCGAGGCGGGCGAAGAAGGCGAGGGCGGCGTGTGCCTCAACGGGGGCGTGT
GCTCCGTGGTCGACGACCAGGCCGTATGCGACTGCTCGAGGACCGGCTTCCGTGGCAAGGACTGCAGCCA
AGAAGACAACAATGTGGAAGGTCTGGCACACCTGATGATGGGCGACCAAGGAAAAGAAGAGTATATTGCC
ACGTTCAAGGGATCTGAATACTTCTGCTACGACTTATCTCAAAACCCCATTCAAAGCAGCAGTGATGAAA
TAACTCTGTCCTTTAAAACTCTTCAAAGGAACGGACTGATGCTTCACACAGGGAAATCAGCTGATTATGT
CAATCTTGCATTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCCTTTGAAGCACTA
GTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCAGGAATCTGCGTC
AGGTGACAATATCAGTGGATGGAATTCTTACCACAACGGGCTACACGCAAGAAGATTACACCATGCTGGG
GTCTGATGACTTTTTCTATGTTGGAGGCAGCCCCAGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAAC
AACTTTATGGGCTGTCTCAAAGAGGTTGTATATAAAAATAATGATGTAAGGCTGGAATTATCGCGACTTG
CCAAGCAAGGAGATCCTAAGATGAAGATTCACGGTGTGGTGGCTTTTAAGTGTGAAAATGTGGCAACCTT
AGACCCAATAACTTTTGAGACCCCGGAATCTTTCATTTCTTTGCCTAAGTGGAATGCAAAGAAAACAGGC
TCAATATCATTTGATTTCCGTACAACGGAGCCAAATGGCCTCATCCTGTTTAGCCATGGCAAGCCAAGAC
ATCAGAAGGATGCCAAGCACCCACAGATGATTAAGGTTGACTTTTTTGCTATTGAGATGCTGGATGGCCA
CTTGTACCTCCTCTTAGACATGGGATCAGGTACTATAAAAATCAAAGCCCTGCAGAAGAAAGTCAATGAT
GGAGAATGGTATCACGTGGATTTCCAACGGGATGGACGGTCAGGTACCATTTCTGTCAACACACTACGCA
CTCCCTACACAGCTCCCGGTGAGAGTGAGATCCTGGACCTAGATGATGAGTTGTACCTGGGTGGCTTGCC
AGAAAATAAGGCTGGCCTAGTCTTCCCTACCGAGGTGTGGACTGCTCTGCTCAACTACGGCTACGTGGGC
TGCATCCGGGACCTATTTATTGATGGCCAGAGCAAAGACATCCGGCAGATGGCGGAAATTCAGAGCACTG
CTGGAGTGAAGCCATCCTGCTCAAAAGAGACAGCAAAACCGTGCCTTAGCAATCCTTGCAAAAACAATGG
CATGTGCAGAGATGGCTGGAACAGATACGTCTGCGATTGCTCCGGAACAGGCTATCTCGGCAGGTCCTGT
GAGAGAGAGGCAACGGTTTTGAGCTACGACGGGAGCATGTTCATGAAAATCCAGCTTCCGGTGGTGATGC
ACACTGAGGCTGAGGACGTGTCCTTGCGGTTCCGATCCCAGCGTGCATATGGTATCCTGATGGCGACCAC
TTCTAGAGACTCTGCAGACACCCTTCGATTGGAGCTAGATGCAGGACGTGTGAAACTCACGGTCAATCTA
GATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCTGAGACCCTTTTTGCTGGCTATAACCTCAATG
ATAATGAATGGCACACAGTGCGTGTGGTTCGGCGAGGAAAAAGTTTAAAGCTAACCGTGGATGATCAACA
AGCCATGACAGGCCAAATGGCAGGTGATCATACAAGGCTGGAGTTTCATAACATAGAGACAGGCATCATC
ACCGAACGACGCTACCTTTCTTCTGTCCCCTCCAATTTCATTGGGCACCTGCAAAGCCTGACATTTAATG
GAATGGCATACATAGACTTGTGCAAAAATGGTGATATAGATTACTGTGAACTCAATGCCAGGTTTGGATT
CAGGAACATCATCGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGCCTTAGCTACATTGCAA
GCCTACACCTCTATGCATCTATTTTTCCAATTCAAGACAACATCTCTAGATGGACTAATTCTGTATAACA
GTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGGTACTTACATTATGTGTTTGACTTGGG
AAACGGTGCTAACCTCATCAAAGGGAGCTCAAACAAACCACTCAACGACAATCAGTGGCACAATGTGATG
ATTTCACGGGACACCAGCAATCTCCACACAGTAAAGATCGACACAAAAATCACAACACAAATCACTGCGG
GAGCCAGAAATCTAGACCTCAAGAGTGACTTGTATATTGGAGGAGTGGCTAAAGAAACATATAAATCCCT
GCCAAAACTGGTCCATGCCAAAGAAGGCTTTCAAGGTTGCCTGGCATCTGTGGACTTGAATGGCAGACTT
CCAGATCTCATCTCGGATGCTCTCTTCTGCAATGGGCAAATTGAGAGAGGATGCGAAGGGCCCAGCACAA
CCTGCCAAGAGGATTCATGTTCAAATCAAGGCGTTTGCTTGCAGCAATGGGATGGCTTCAGCTGTGACTG
TAGCATGACTTCCTTCAGTGGCCCACTCTGCAATGACCCTGGGACAACATATATCTTTAGCAAAGGTGGT
GGACAGATTACATATAAGTGGCCTCCCAATGACCGCCCCAGTACACGAGCAGACAGGCTGGCCATCGGAT
TTAGCACTGTCCAGAAGGAAGCCGTGTTGGTGCGTGTGGACAGTTCCTCAGGACTGGGTGACTACCTGGA
GCTGCACATACACCAAGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATCGAAGAG
TCTAATGCAATCATTAATGATGGGAAATACCATGTAGTACGTTTCACAAGGAGTGGTGGCAATGCCACGT
TACAGGTGGACAGCTGGCCAGTTATCGAACGCTACCCTGCAGGAAACAATGATAACGAGCGCCTGGCGAT
TGCTAGACAGCGAATTCCATATCGACTTGGTCGAGTAGTTGATGAATGGCTACTCGACAAAGGGCGTCAG
CTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCC
AGCTCTCTGGTCTTTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCAGAGAACGATGCCAACATCGC
CATAGTGGGGAATGTGAGGCTGGTCGGTGAAGTGCCTTCCTCTATGACAACTGAGTCGACAGCCACTGCC
ATGCAGTCTGAGATGTCCACCTCAATCATGGAGACCACCACAACCCTGGCTACCAGCACAGCTAGAAGAG
GCAAGCCCCCCACAAAGGAACCCATCAGCCAGACCACAGATGACATCCTTGTGGCCTCGGCAGAGTGTCC
CAGTGACGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAACCCCACCAGAGTAGGT
GGCCGTGAACCATACCCAGGCTCTGCAGAGGTGATTCGGGAGTCCAGCAGTACCACTGGCATGGTGGTGG
GGATTGTCGCAGCAGCCGCTCTGTGCATCCTCATCCTCCTCTATGCCATGTACAAGTACAGGAACCGGGA
TGAAGGGTCGTACCACGTGGATGAGAGTCGAAACTACATCAGTAACTCAGCACAGTCCAATGGGGCTGTG
GTCAAGGAGAAGCAACCCAGCAGTGCTAAAAGCGCCAACAAAAACAAGAAAAACAAGGATAAGGAGTATT
ACGTCTGA


AGCGGACCGACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCC
TGGATTACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-RsrII     
ACCN NM_177284
ORF Size 4488 bp
Insert Size 4488
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_177284.2, NP_796258.2
RefSeq Size 9004
RefSeq ORF 4488
Locus ID 18189
Gene Summary This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]

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