APBB3 (NM_133174) Human Tagged ORF Clone

CAT#: RC202016

APBB3 (Myc-DDK-tagged)-Human amyloid beta (A4) precursor protein-binding, family B, member 3 (APBB3), transcript variant 1

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: APBB3
• Synonyms: FE65L2; SRA
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC202016 representing NM_133174
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCTGGGCAAGGATTACATGCTGGCCATCATTCTGGTCAACTGCGATGATGACTTGTGGGGGGACCACA
  GTCTGGAGGTGGAGGCTGGCCTGCCTCCTGGCTGGAGGAAGATCCACGATGCTGCAGGTACTTACTACTG
  GCATGTACCCAGCGGTAGCACCCAGTGGCAGCGCCCAACCTGGGAACTAGGAGATGCAGAGGACCCAGGC
  ACGGGAACGGAGGGGATCTGGGGACTGCGGCCCCCCAAAGGGAGATCCTTCTCCAGCCTGGAGAGTTCAC
  TGGACCGGAGTAACTCTCTGTCCTGGTATGGTGGGGAATCCTACATCCAGAGCATGGAGCCAGGGGCTAA
  GTGCTTTGCAGTCCGCTCTCTGGGCTGGGTAGAGGTACCTGAAGAGGACCTGGCACCGGGGAAGAGCAGT
  ATTGCAGTCAATAACTGTATCCAGCAGCTGGCCCAGACCCGCAGCCGGAGCCAGCCTCCAGATGGTGCCT
  GGGGTGAGGGCCAGAACATGCTGATGATCCTGAAGAAGGATGCCATGAGCCTAGTGAATCCCCTGGACCA
  CAGTCTGATCCACTGCCAGCCTCTGGTGCACATCCGTGTGTGGGGCGTGGGGAGCTCCAAGGGCCGGGAC
  TTCGCTTTTGTGGCAAGTGACAAAGATAGCTGTATGCTCAAGTGCCATGTGTTTTGCTGTGATGTCCCTG
  CCAAGGCCATTGCCAGTGCCCTACATGGGCTTTGTGCCCAGATCTTGTCAGAGCGAGTAGAGGTCAGTGG
  TGATGCCTCTTGCTGCTCCCCAGACCCCATCTCTCCTGAAGACCTGCCACGGCAAGTGGAGCTGCTGGAT
  GCGGTAAGCCAAGCTGCTCAGAAGTACGAGGCACTGTATATGGGGACACTGCCAGTCACCAAGGCCATGG
  GCATGGATGTGCTGAACGAGGCCATTGGTACCCTCACCGCCAGGGGGGACCGGAATGCCTGGGTCCCCAC
  CATGCTCAGTGTGTCTGACTCTCTCATGACTGCACACCCCATTCAGGCAGAGGCCAGTACAGAGGAGGAG
  CCATTGTGGCAGTGCCCTGTGCGCCTTGTGACATTTATTGGTGTTGGCCGCGACCCACACACCTTTGGCC
  TCATCGCTGACCTGGGCCGTCAGAGCTTCCAGTGCGCAGCCTTCTGGTGCCAGCCCCATGCAGGGGGACT
  CTCTGAAGCTGTGCAGGCTGCCTGTATGGTTCAGTACCAGAAGTGTCTTGTGGCCTCTGCAGCTCGAGGC
  AAGGCCTGGGGTGCCCAGGCCCGTGCCCGCCTGCGGCTCAAGCGGACCAGCTCCATGGATTCCCCAGGAG
  GTCCCCTGCCCCTCCCCCTGCTCAAAGGAGGGGTTGGCGGTGCAGGGGCAACCCCTCGAAAGCGGGGTGT
  CTTCTCTTTTCTTGATGCCTTCCGGCTGAAACCCTCTCTGCTCCATATGCCC
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC202016 representing NM_133174
  Red=Cloning site Green=Tags(s)
  
  MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPG
  TGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSS
  IAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRD
  FAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLD
  AVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEE
  PLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARG
  KAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_133174
• ORF Size: 1452 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_133174.1, NM_133174.2, NP_573420.1, NP_573420.2
• RefSeq Size: 2140
• RefSeq ORF: 1455
• Locus ID: 10307
• Domains: WW, PID
• MW: 52.3 kDa
• Gene Summary: The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]