Serine Palmitoyltransferase (SPTLC2) (NM_004863) Human Tagged ORF Clone

CAT#: RC202420L1

Lenti ORF clone of Human serine palmitoyltransferase, long chain base subunit 2 (SPTLC2), Myc-DDK-tagged

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: SPTLC2
• Synonyms: hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
• Vector: pLenti-C-Myc-DDK
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202420).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_004863
• ORF Size: 1686 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004863.2, NP_004854.1
• RefSeq Size: 8164
• RefSeq ORF: 1689
• Locus ID: 9517
• Domains: aminotran_1_2
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism
• MW: 62.9 kDa
• Gene Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]