MSH6 (NM_000179) Human Tagged ORF Clone
CAT#: RC202469L3
- LentiORF®
Lenti-ORF clone of MSH6 (Myc-DDK-tagged)-Human mutS homolog 6 (E. coli) (MSH6)
"NM_000179" in other vectors (7)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | MSH6 |
Synonyms | GTBP; GTMBP; HNPCC5; HSAP; p160 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC202469).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_000179 |
ORF Size | 4080 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_000179.1, NP_000170.1 |
RefSeq Size | 4264 bp |
RefSeq ORF | 4083 bp |
Locus ID | 2956 |
Cytogenetics | 2p16.3 |
Domains | PWWP, MutS_V, MutS_I, MutS_III, MutS_II, MutS_IV |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
Protein Pathways | Colorectal cancer, Mismatch repair, Pathways in cancer |
MW | 152.6 kDa |
Gene Summary | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013] |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC120035 | MSH6 (untagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 310.00 |
|
SC320735 | MSH6 (untagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 310.00 |
|
RC202469 | MSH6 (Myc-DDK-tagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 98.00 |
|
RG202469 | MSH6 (GFP-tagged) - Human mutS homolog 6 (E. coli) (MSH6) |
USD 1,340.00 |
|
RC202469L1 | Lenti-ORF clone of MSH6 (Myc-DDK-tagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 1,420.00 |
|
RC202469L2 | Lenti-ORF clone of MSH6 (mGFP-tagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 1,420.00 |
|
RC202469L4 | Lenti-ORF clone of MSH6 (mGFP-tagged)-Human mutS homolog 6 (E. coli) (MSH6) |
USD 1,420.00 |
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