HLA DMB (HLA-DMB) (NM_002118) Human Tagged ORF Clone
CAT#: RC203811L4
- LentiORF®
Lenti ORF clone of Human major histocompatibility complex, class II, DM beta (HLA-DMB), mGFP tagged
"NM_002118" in other vectors (4)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | HLA-DMB |
Synonyms | D6S221E; RING7 |
Vector | pLenti-C-mGFP-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC203811).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_002118 |
ORF Size | 789 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_002118.3, NP_002109.1 |
RefSeq Size | 1412 |
RefSeq ORF | 792 |
Locus ID | 3109 |
Domains | MHC_II_beta, ig, IGc1 |
Protein Families | Transmembrane |
Protein Pathways | Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis |
MW | 28.9 kDa |
Gene Summary | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC118844 | HLA (untagged)-Human major histocompatibility complex, class II, DM beta (HLA-DMB) |
USD 310.00 |
|
RC203811 | HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DM beta (HLA-DMB) |
USD 98.00 |
|
RG203811 | HLA (GFP-tagged) - Human major histocompatibility complex, class II, DM beta (HLA-DMB) |
USD 460.00 |
|
RC203811L3 | Lenti ORF clone of Human major histocompatibility complex, class II, DM beta (HLA-DMB), Myc-DDK-tagged |
USD 620.00 |
{0} Product Review(s)
Be the first one to submit a review