Viperin (RSAD2) (NM_080657) Human Tagged ORF Clone
CAT#: RC205066L2
- LentiORF®
Lenti ORF clone of Human radical S-adenosyl methionine domain containing 2 (RSAD2), mGFP tagged
"NM_080657" in other vectors (7)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | RSAD2 |
Synonyms | 2510004L01Rik; cig5; cig33; vig1 |
Vector | pLenti-C-mGFP |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC205066).
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Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_080657 |
ORF Size | 1083 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_080657.4, NP_542388.2 |
RefSeq Size | 3512 |
RefSeq ORF | 1086 |
Locus ID | 91543 |
Domains | Elp3, Radical_SAM |
MW | 42.2 kDa |
Gene Summary | Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. [UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
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SC120395 | RSAD2 (untagged)-Human radical S-adenosyl methionine domain containing 2 (RSAD2) |
USD 760.00 |
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SC320966 | RSAD2 (untagged)-Human radical S-adenosyl methionine domain containing 2 (RSAD2) |
USD 760.00 |
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RC205066 | RSAD2 (Myc-DDK-tagged)-Human radical S-adenosyl methionine domain containing 2 (RSAD2) |
USD 420.00 |
|
RG205066 | RSAD2 (GFP-tagged) - Human radical S-adenosyl methionine domain containing 2 (RSAD2) |
USD 460.00 |
|
RC205066L1 | Lenti ORF clone of Human radical S-adenosyl methionine domain containing 2 (RSAD2), Myc-DDK-tagged |
USD 768.00 |
|
RC205066L3 | Lenti ORF clone of Human radical S-adenosyl methionine domain containing 2 (RSAD2), Myc-DDK-tagged |
USD 620.00 |
|
RC205066L4 | Lenti ORF clone of Human radical S-adenosyl methionine domain containing 2 (RSAD2), mGFP tagged |
USD 620.00 |
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