Viperin (RSAD2) (NM_080657) Human Untagged Clone

CAT#: SC320966

RSAD2 (untagged)-Human radical S-adenosyl methionine domain containing 2 (RSAD2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RSAD2
• Synonyms: 2510004L01Rik; cig5; cig33; vig1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_080657.4 GCTCTGCTCCAGGCATCTGCCACAATGTGGGTGCTTACACCTGCTGCTTTTGCTGGGAAG
  CTCTTGAGTGTGTTCAGGCAACCTCTGAGCTCTCTGTGGAGGAGCCTGGTCCCGCTGTTC
  TGCTGGCTGAGGGCAACCTTCTGGCTGCGAGCTACCAAGAGGAGAAAGCAGCAGCTGGTC
  CTGAGAGGGCCAGATGAGACCAAAGAGGAGGAAGAGGACCCTCCTCTGCCCACCACCCCA
  ACCAGCGTCAACTATCACTTCACTCGCCAGTGCAACTACAAATGCGGCTTCTGTTTCCAC
  ACAGCCAAAACATCCTTTGTGCTGCCCCTTGAGGAAGCAAAGAGAGGATTGCTTTTGCTT
  AAGGAAGCTGGTATGGAGAAGATCAACTTTTCAGGTGGAGAGCCATTTCTTCAAGACCGG
  GGAGAATACCTGGGCAAGTTGGTGAGGTTCTGCAAAGTAGAGTTGCGGCTGCCCAGCGTG
  AGCATCGTGAGCAATGGAAGCCTGATCCGGGAGAGGTGGTTCCAGAATTATGGTGAGTAT
  TTGGACATTCTCGCTATCTCCTGTGACAGCTTTGACGAGGAAGTCAATGTCCTTATTGGC
  CGTGGCCAAGGAAAGAAGAACCATGTGGAAAACCTTCAAAAGCTGAGGAGGTGGTGTAGG
  GATTATAGAGTCGCTTTCAAGATAAATTCTGTCATTAATCGTTTCAACGTGGAAGAGGAC
  ATGACGGAACAGATCAAAGCACTAAACCCTGTCCGCTGGAAAGTGTTCCAGTGCCTCTTA
  ATTGAGGGTGAGAATTGTGGAGAAGATGCTCTAAGAGAAGCAGAAAGATTTGTTATTGGT
  GATGAAGAATTTGAAAGATTCTTGGAGCGCCACAAAGAAGTGTCCTGCTTGGTGCCTGAA
  TCTAACCAGAAGATGAAAGACTCCTACCTTATTCTGGATGAATATATGCGCTTTCTGAAC
  TGTAGAAAGGGACGGAAGGACCCTTCCAAGTCCATCCTGGATGTTGGTGTAGAAGAAGCT
  ATAAAATTCAGTGGATTTGATGAAAAGATGTTTCTGAAGCGAGGAGGAAAATACATATGG
  AGTAAGGCTGATCTGAAGCTGGATTGGTAGAGCGGAAAGTGGAACGAGACTTCAACACAC
  CAGTGGGAAAACTCCTAGAGTAACTGCCATTGTCTGCAATACTATCCCGTTGGTATTTCC
  CAGTGGCTGAAAACCTGATTTTCTGCTGCACGTGGCATCTGATTACCTGTGGTCACTGAA
  CACACGAATAACTTGGATAGCAAATCCTGAGACAATGGAAAACCATTAACTTTACTTCAT
  TGGCTTATAACCTTGTTGTTATTGAAACAGCACTTCTGTTTTTGAGTTTGTTTTAGCTAA
  AAAGAAGGAATACACACAGGAATAATGACCCCAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_080657.4 unedited
  GACCATTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCTTACGGCCGGGGGCTCT
  GCTCCAGGCATCTGCCACAATGTGGGTGCTTACACCTGCTGCTTTTGCTGGGAAGCTCTT
  GAGTGTGTTCAGGCAACCTCTGAGCTCTCTGTGGAGGAGCCTGGTCCCGCTGTTCTGCTG
  GCTGAGGGCAACCTTCTGGCTGCGAGCTACCAAGAGGAGAAAGCAGCAGCTGGTCCTGAG
  AGGGCCAGATGAGACCAAAGAGGAGGAAGAGGACCCTCCTCTGCCCACCACCCCAACCAG
  CGTCAACTATCACTTCACTCGCCAGTGCATTTACTAATGCGGCTTCTGTTTCCACACAGC
  CAAAACATCCTTTGTGCTGCCCCTTGAGGAAGCAAAGAGAGGATTGCTTTTGCTTAAGGA
  AGCTGGTATGGAGAAGATCAACTTTTCAGGTGGAGAGCCATTTCTTCAAGACCGGGGAGA
  ATACCTGGGCAAGTTGGTGAGGTTCTGCAAAGTAGAGTTGCGGCTGCCCAGCGTGAGCAT
  CGTGAGCAATGGAAGCCTGATCCGGGAGAGGTGGTTCCAGAATTATGGTGAGTATTTGGA
  CATTCTCGCTATCTCCTGTGACAGCTTTGACGAGGAAGTCAATGTCCTTATTGGCCGTGG
  CCAAGGAAAGAAGACCCATGTGGAAAACCTTCAAAAGCTGAGGAGTGGTGTAGGGATGTA
  TAGAGTCGCTTTCAAGATAAATTCTGTCATTAATCGTTTCAACGTGGAGAGGACATGACG
  GGACAGATCAAAGCACTAAACCCTGTCCGCTGGAAGTGTTCCAGTGCTCTTATTGAGGGT
  GAGATTGGTGGAGAAGATGCTCTAGAGAGCAAACGATTTGTTATGTGATGATGATTTGAG
  ATTCTTGGATCGCCCAAGAGTGTCCTGCTGGTGCCTTGATTCTACCGGAGAATGAAGAA
• Restriction Sites: Please inquire
• ACCN: NM_080657
• ORF Size: 1086 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_080657.4, NP_542388.2
• RefSeq Size: 3512
• RefSeq ORF: 1086
• Locus ID: 91543
• Domains: Elp3, Radical_SAM
• Gene Summary: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. [UniProtKB/Swiss-Prot Function]