Cullin 5 (CUL5) (NM_003478) Human Tagged ORF Clone
CAT#: RC209273L2
- LentiORF®
Lenti ORF clone of Human cullin 5 (CUL5), mGFP tagged
"NM_003478" in other vectors (6)
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | mGFP |
Symbol | CUL5 |
Synonyms | CUL-5; VACM-1; VACM1 |
Vector | pLenti-C-mGFP |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC209273).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_003478 |
ORF Size | 2340 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_003478.3, NP_003469.2 |
RefSeq Size | 6408 |
RefSeq ORF | 2343 |
Locus ID | 8065 |
Domains | CULLIN |
Protein Families | Druggable Genome |
Protein Pathways | Ubiquitin mediated proteolysis |
MW | 91 kDa |
Gene Summary | Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. [UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC310119 | CUL5 (untagged)-Human cullin 5 (CUL5) |
USD 760.00 |
|
RC209273 | CUL5 (Myc-DDK-tagged)-Human cullin 5 (CUL5) |
USD 420.00 |
|
RG209273 | CUL5 (GFP-tagged) - Human cullin 5 (CUL5) |
USD 460.00 |
|
RC209273L1 | Lenti ORF clone of Human cullin 5 (CUL5), Myc-DDK-tagged |
USD 620.00 |
|
RC209273L3 | Lenti ORF clone of Human cullin 5 (CUL5), Myc-DDK-tagged |
USD 620.00 |
|
RC209273L4 | Lenti ORF clone of Human cullin 5 (CUL5), mGFP tagged |
USD 620.00 |
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